Genetics of gastric cancer

Mairi H. McLean*, Emad M. El-Omar

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

332 Citations (Scopus)


Gastric cancer remains highly prevalent and accounts for a notable proportion of global cancer mortality. This cancer is also associated with poor survival rates. Understanding the genetic basis of gastric cancer will offer insights into its pathogenesis, help identify new biomarkers and novel treatment targets, aid prognostication and could be central to developing individualized treatment strategies in the future. An inherited component contributes to <3% of gastric cancers; the majority of genetic changes associated with gastric cancer are acquired. Over the past few decades, advances in technology and high-throughput analysis have improved understanding of the molecular aspects of the pathogenesis of gastric cancer. These aspects are multifaceted and heterogeneous and represent a wide spectrum of several key genetic influences, such as chromosomal instability, microsatellite instability, changes in microRNA profile, somatic gene mutations or functional single nucleotide polymorphisms. These genetic aspects of the pathogenesis of gastric cancer will be addressed in this Review

Original languageEnglish
Pages (from-to)664-674
Number of pages11
JournalNature Reviews Gastroenterology & Hepatology
Issue number11
Early online date19 Aug 2014
Publication statusPublished - Nov 2014


  • Cancer genetics
  • Gastric cancer
  • stomach


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