Greasing the path to BAX/BAK activation

Emilie Hollville, Seamus J. Martin*

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

4 Citations (Scopus)


BAX/BAK activation leading to mitochondrial outer-membrane permeabilization is a key commitment point in apoptosis. Chipuk et al. now identify two sphingolipids as specific cofactors for BAX/BAK activation that lower the threshold for apoptosis-associated cytochrome c release. Association of mitochondria with other cellular membrane compartments is required for BAK/BAX exposure to these sphingolipids.

Original languageEnglish
Pages (from-to)845-846
Number of pages2
Issue number5
Publication statusPublished - 2 Mar 2012


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