Hazard and risk assessment of human exposure to toxic metals using in vitro digestion assay

Hani A. Alhadrami; Lenka Mbadugha; Graeme I. Paton

doi:10.1080/09542299.2016.1180961

Hazard and risk assessment of human exposure to toxic metals using in vitro digestion assay

Hani A. Alhadrami^*, Lenka Mbadugha, Graeme I. Paton

^*Corresponding author for this work

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Abstract

Clean-up targets for toxic metals require that the site be “fit for purpose”. This means that targets are set with respect to defined receptors that reflect intended land-use. In this study, the likely threat of human exposure to toxic metals has been evaluated by simulating the human digestion process in vitro. The effects of key attributes (i.e. sample fraction size, pH, Kd and total metal concentrations) on the bioavailability of Cu and Ni were also investigated. Total metal concentration was the key explanatory factor for Cu and Ni bioavailability. A comparative ranking of metal concentrations in the context of tolerable daily intakes for Cu and Ni confirmed that the pH has the greatest impact on metals bioavailability. Rapid screening of key attributes and total toxic metal doses can reveal the relative hazard imposed on human, and this approach should be considered when defining threshold values for human protection.

Original language	English
Pages (from-to)	78-87
Number of pages	10
Journal	Chemical Speciation and Bioavailability
Volume	28
Issue number	1-4
Early online date	12 May 2016
DOIs	https://doi.org/10.1080/09542299.2016.1180961
Publication status	Published - 2016

Bibliographical note

Acknowledgements
The authors, acknowledge with thanks DSR technical and financial support.

Funding

This project was funded by the Deanship of Scientific Research (DSR), King Abdulaziz University, Jeddah, under grant no. 1434-142-514. The authors, therefore, acknowledge with thanks DSR technical and financial support.

Keywords

Oral bioavailability
human exposure
in vitro digestion assay
hazard and risk assessment
copper and nickel
TDI
CONTAMINATED SOILS
ARSENIC BIOACCESSIBILITY
GASTROINTESTINAL METHOD
TRACE-ELEMENTS
MINE TAILINGS
PARTICLES
BIOAVAILABILITY
EXTRACTION
CADMIUM
CANADA

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/09542299.2016.1180961Licence: CC BY-NC

Hazard and risk assessment of human exposure to toxic metals using in vitro digestion assay
© 2016 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Final published version, 980 KBLicence: CC BY-NC

Graeme Paton
- Biological Sciences, Aberdeen Centre For Environmental Sustainability - Head of School of Biological Sciences, Chair in Biological Sciences
- Engineering, National Decommissioning Centre
- Centre for Energy Transition
- Marine Alliance for Science and Technology for Scotland (MASTS)
Person: Academic

Cite this

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title = "Hazard and risk assessment of human exposure to toxic metals using in vitro digestion assay",

abstract = "Clean-up targets for toxic metals require that the site be “fit for purpose”. This means that targets are set with respect to defined receptors that reflect intended land-use. In this study, the likely threat of human exposure to toxic metals has been evaluated by simulating the human digestion process in vitro. The effects of key attributes (i.e. sample fraction size, pH, Kd and total metal concentrations) on the bioavailability of Cu and Ni were also investigated. Total metal concentration was the key explanatory factor for Cu and Ni bioavailability. A comparative ranking of metal concentrations in the context of tolerable daily intakes for Cu and Ni confirmed that the pH has the greatest impact on metals bioavailability. Rapid screening of key attributes and total toxic metal doses can reveal the relative hazard imposed on human, and this approach should be considered when defining threshold values for human protection.",

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note = "Acknowledgements The authors, acknowledge with thanks DSR technical and financial support. Funding This project was funded by the Deanship of Scientific Research (DSR), King Abdulaziz University, Jeddah, under grant no. 1434-142-514. The authors, therefore, acknowledge with thanks DSR technical and financial support.",

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AB - Clean-up targets for toxic metals require that the site be “fit for purpose”. This means that targets are set with respect to defined receptors that reflect intended land-use. In this study, the likely threat of human exposure to toxic metals has been evaluated by simulating the human digestion process in vitro. The effects of key attributes (i.e. sample fraction size, pH, Kd and total metal concentrations) on the bioavailability of Cu and Ni were also investigated. Total metal concentration was the key explanatory factor for Cu and Ni bioavailability. A comparative ranking of metal concentrations in the context of tolerable daily intakes for Cu and Ni confirmed that the pH has the greatest impact on metals bioavailability. Rapid screening of key attributes and total toxic metal doses can reveal the relative hazard imposed on human, and this approach should be considered when defining threshold values for human protection.

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KW - GASTROINTESTINAL METHOD

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KW - MINE TAILINGS

KW - PARTICLES

KW - BIOAVAILABILITY

KW - EXTRACTION

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ER -

Hazard and risk assessment of human exposure to toxic metals using in vitro digestion assay

Abstract

Bibliographical note

Keywords

UN SDGs

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Graeme Paton

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