Clean-up targets for toxic metals require that the site be “fit for purpose”. This means that targets are set with respect to defined receptors that reflect intended land-use. In this study, the likely threat of human exposure to toxic metals has been evaluated by simulating the human digestion process in vitro. The effects of key attributes (i.e. sample fraction size, pH, Kd and total metal concentrations) on the bioavailability of Cu and Ni were also investigated. Total metal concentration was the key explanatory factor for Cu and Ni bioavailability. A comparative ranking of metal concentrations in the context of tolerable daily intakes for Cu and Ni confirmed that the pH has the greatest impact on metals bioavailability. Rapid screening of key attributes and total toxic metal doses can reveal the relative hazard imposed on human, and this approach should be considered when defining threshold values for human protection.
The authors, acknowledge with thanks DSR technical and financial support.
This project was funded by the Deanship of Scientific Research (DSR), King Abdulaziz University, Jeddah, under grant no. 1434-142-514. The authors, therefore, acknowledge with thanks DSR technical and financial support.
- Oral bioavailability
- human exposure
- in vitro digestion assay
- hazard and risk assessment
- copper and nickel
- CONTAMINATED SOILS
- ARSENIC BIOACCESSIBILITY
- GASTROINTESTINAL METHOD
- MINE TAILINGS
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- Biological Sciences, Aberdeen Centre For Environmental Sustainability - Head of School of Biological Sciences, Chair in Biological Sciences
- Engineering, National Decommissioning Centre
- Centre for Energy Transition
- Marine Alliance for Science and Technology for Scotland (MASTS)