Hiding in Plain Sight: Soluble Immunomodulatory Receptors

Lekh N Dahal; Herbert Schwarz; Frank J Ward

doi:10.1016/j.it.2018.08.004

Hiding in Plain Sight: Soluble Immunomodulatory Receptors

Lekh N Dahal (Corresponding Author), Herbert Schwarz, Frank J Ward

Medical Sciences

Research output: Contribution to journal › Article › peer-review

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Abstract

Alternatively spliced natural soluble isoforms of immunomodulatory receptors [cytotoxic T lymphocyte antigen-4 (CTLA-4), 4-1BB, and programmed death-1 (PD-1)/PD-L1] have been overlooked in favor of their cell-surface-bound counterparts that have generated blockbuster antibodies for the treatment of cancer. We propose that the soluble variants of these receptors contribute to immune regulation and offer potential as targets for immunotherapy.

Original language	English
Pages (from-to)	771-774
Number of pages	4
Journal	Trends in Immunology
Volume	39
Issue number	10
Early online date	5 Sept 2018
DOIs	https://doi.org/10.1016/j.it.2018.08.004
Publication status	Published - Oct 2018

Bibliographical note

We thank Professor Mark S. Cragg, Centre for Cancer Immunology, Faculty of Medicine, University of Southampton, Southampton, UK for critical reading of the manuscript.

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Cite this

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abstract = "Alternatively spliced natural soluble isoforms of immunomodulatory receptors [cytotoxic T lymphocyte antigen-4 (CTLA-4), 4-1BB, and programmed death-1 (PD-1)/PD-L1] have been overlooked in favor of their cell-surface-bound counterparts that have generated blockbuster antibodies for the treatment of cancer. We propose that the soluble variants of these receptors contribute to immune regulation and offer potential as targets for immunotherapy.",

author = "Dahal, {Lekh N} and Herbert Schwarz and Ward, {Frank J}",

note = "We thank Professor Mark S. Cragg, Centre for Cancer Immunology, Faculty of Medicine, University of Southampton, Southampton, UK for critical reading of the manuscript. ",

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AU - Dahal, Lekh N

AU - Schwarz, Herbert

AU - Ward, Frank J

N1 - We thank Professor Mark S. Cragg, Centre for Cancer Immunology, Faculty of Medicine, University of Southampton, Southampton, UK for critical reading of the manuscript.

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AB - Alternatively spliced natural soluble isoforms of immunomodulatory receptors [cytotoxic T lymphocyte antigen-4 (CTLA-4), 4-1BB, and programmed death-1 (PD-1)/PD-L1] have been overlooked in favor of their cell-surface-bound counterparts that have generated blockbuster antibodies for the treatment of cancer. We propose that the soluble variants of these receptors contribute to immune regulation and offer potential as targets for immunotherapy.

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DO - 10.1016/j.it.2018.08.004

M3 - Article

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JO - Trends in Immunology

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Hiding in Plain Sight: Soluble Immunomodulatory Receptors

Abstract

Bibliographical note

UN SDGs

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