Hip Shape as a Predictor of Osteoarthritis Progression in a Prospective Population Cohort

Harbeer G.  Ahedi; Richard M. Aspden; Leigh C.  Blizzard; Fiona R. Saunders; Flavia M.  Cicuttini; Dawn A.  Aitken; Graeme Jones; Jennifer S. Gregory

doi:10.1002/acr.23166

Hip Shape as a Predictor of Osteoarthritis Progression in a Prospective Population Cohort

Harbeer G. Ahedi, Richard M. Aspden, Leigh C. Blizzard , Fiona R. Saunders, Flavia M. Cicuttini, Dawn A. Aitken, Graeme Jones, Jennifer S. Gregory

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Abstract

Objective: Hip morphology plays a significant role in the incidence and progression of hip osteoarthritis (OA). We hypothesized that hip shape would also associate with other key factors and tested this in a longitudinal community-based cohort combining radiographic, MRI, DXA, and clinical data.

Methods: Baseline dual-energy X-ray absorptiometry (DXA) images of the left hip of 831 subjects from the Tasmanian Older Adult Cohort (TASOAC) were analyzed using an 85-point statistical shape model. Hip pain was assessed by WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index) and muscle strength was measured by a dynamometer. Hip structural changes were assessed using MRI and Radiographic OA (ROA) using plain radiographs.

Results: Six shape modes described 68% of shape variation. At baseline, modes 1, 2, 4 and 6 were associated with hip ROA, modes 1, 3, 4 and 6 correlated with hip cartilage volume and all except mode 2 with muscle strength. Higher mode 1, and lower mode 3 and 6 scores at baseline predicted hip pain at follow-up and higher mode 1 and mode 2 scores were associated with hip effusion-synovitis. Greater scores for mode 2 (decreasing acetabular coverage) and lower mode 4 (non-spherical femoral head) at baseline predicted 10-year total hip replacement (THR); while mode 4 alone correlated with bone marrow lesions (BMLs), effusion-synovitis, and increased cartilage signal.

Conclusions: Hip shape is associated with ROA, THR, hip pain, effusion-synovitis, BMLs, muscle strength and hip structural changes. These data suggest that different shape modes reflect multiple facets of hip osteoarthritis. This article is protected by copyright. All rights reserved.

Original language	English
Pages (from-to)	1566-1573
Number of pages	8
Journal	Arthritis Care & Research
Volume	69
Issue number	10
Early online date	27 Sept 2017
DOIs	https://doi.org/10.1002/acr.23166
Publication status	Published - Oct 2017

Bibliographical note

Acknowledgements
A special thanks go to the participants of the TASOAC study. We thank Catrina Boon and Pip Boon for their contributions.

Funding sources
The TASOAC study was supported by the National Health and Medical Research Council of Australia, Tasmanian Community Fund, Masonic Centenary Medical Research Foundation, Royal Hobart Hospital Research Foundation and Arthritis Foundation of Australia. This project was funded by OARSI (Osteoarthritis Research Society International) collaborative scholarship.

HA was funded by an Australian Government Postgraduate Award, and this study was supported by an OARSI collaborative scholarship to HA and held in Aberdeen.

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Accepted Manuscript
This is the peer reviewed version of the following article: Ahedi, H. G., Aspden, R. M., Blizzard, L. C., Saunders, F. R., Cicuttini, F. M., Aitken, D. A., Jones, G. and Gregory, J. S. (2017), Hip Shape as a Predictor of Osteoarthritis Progression in a Prospective Population Cohort. Arthritis Care & Research, 69: 1566–1573., which has been published in final form at 10.1002/acr.23166. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Accepted author manuscript, 902 KBLicence: Unspecified

Jenny Gregory
Person: Academic Related - Scholarship

Cite this

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title = "Hip Shape as a Predictor of Osteoarthritis Progression in a Prospective Population Cohort",

abstract = "Objective: Hip morphology plays a significant role in the incidence and progression of hip osteoarthritis (OA). We hypothesized that hip shape would also associate with other key factors and tested this in a longitudinal community-based cohort combining radiographic, MRI, DXA, and clinical data.Methods: Baseline dual-energy X-ray absorptiometry (DXA) images of the left hip of 831 subjects from the Tasmanian Older Adult Cohort (TASOAC) were analyzed using an 85-point statistical shape model. Hip pain was assessed by WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index) and muscle strength was measured by a dynamometer. Hip structural changes were assessed using MRI and Radiographic OA (ROA) using plain radiographs.Results: Six shape modes described 68% of shape variation. At baseline, modes 1, 2, 4 and 6 were associated with hip ROA, modes 1, 3, 4 and 6 correlated with hip cartilage volume and all except mode 2 with muscle strength. Higher mode 1, and lower mode 3 and 6 scores at baseline predicted hip pain at follow-up and higher mode 1 and mode 2 scores were associated with hip effusion-synovitis. Greater scores for mode 2 (decreasing acetabular coverage) and lower mode 4 (non-spherical femoral head) at baseline predicted 10-year total hip replacement (THR); while mode 4 alone correlated with bone marrow lesions (BMLs), effusion-synovitis, and increased cartilage signal.Conclusions: Hip shape is associated with ROA, THR, hip pain, effusion-synovitis, BMLs, muscle strength and hip structural changes. These data suggest that different shape modes reflect multiple facets of hip osteoarthritis. This article is protected by copyright. All rights reserved.",

author = "Ahedi, {Harbeer G.} and Aspden, {Richard M.} and Blizzard, {Leigh C.} and Saunders, {Fiona R.} and Cicuttini, {Flavia M.} and Aitken, {Dawn A.} and Graeme Jones and Gregory, {Jennifer S.}",

note = "Acknowledgements A special thanks go to the participants of the TASOAC study. We thank Catrina Boon and Pip Boon for their contributions. Funding sources The TASOAC study was supported by the National Health and Medical Research Council of Australia, Tasmanian Community Fund, Masonic Centenary Medical Research Foundation, Royal Hobart Hospital Research Foundation and Arthritis Foundation of Australia. This project was funded by OARSI (Osteoarthritis Research Society International) collaborative scholarship. HA was funded by an Australian Government Postgraduate Award, and this study was supported by an OARSI collaborative scholarship to HA and held in Aberdeen.",

year = "2017",

month = oct,

doi = "10.1002/acr.23166",

language = "English",

volume = "69",

pages = "1566--1573",

journal = "Arthritis Care & Research",

issn = "0893-7524",

publisher = "Wiley-Blackwell ",

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T1 - Hip Shape as a Predictor of Osteoarthritis Progression in a Prospective Population Cohort

AU - Ahedi, Harbeer G.

AU - Aspden, Richard M.

AU - Blizzard , Leigh C.

AU - Saunders, Fiona R.

AU - Cicuttini, Flavia M.

AU - Aitken, Dawn A.

AU - Jones, Graeme

AU - Gregory, Jennifer S.

N1 - Acknowledgements A special thanks go to the participants of the TASOAC study. We thank Catrina Boon and Pip Boon for their contributions. Funding sources The TASOAC study was supported by the National Health and Medical Research Council of Australia, Tasmanian Community Fund, Masonic Centenary Medical Research Foundation, Royal Hobart Hospital Research Foundation and Arthritis Foundation of Australia. This project was funded by OARSI (Osteoarthritis Research Society International) collaborative scholarship. HA was funded by an Australian Government Postgraduate Award, and this study was supported by an OARSI collaborative scholarship to HA and held in Aberdeen.

PY - 2017/10

Y1 - 2017/10

N2 - Objective: Hip morphology plays a significant role in the incidence and progression of hip osteoarthritis (OA). We hypothesized that hip shape would also associate with other key factors and tested this in a longitudinal community-based cohort combining radiographic, MRI, DXA, and clinical data.Methods: Baseline dual-energy X-ray absorptiometry (DXA) images of the left hip of 831 subjects from the Tasmanian Older Adult Cohort (TASOAC) were analyzed using an 85-point statistical shape model. Hip pain was assessed by WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index) and muscle strength was measured by a dynamometer. Hip structural changes were assessed using MRI and Radiographic OA (ROA) using plain radiographs.Results: Six shape modes described 68% of shape variation. At baseline, modes 1, 2, 4 and 6 were associated with hip ROA, modes 1, 3, 4 and 6 correlated with hip cartilage volume and all except mode 2 with muscle strength. Higher mode 1, and lower mode 3 and 6 scores at baseline predicted hip pain at follow-up and higher mode 1 and mode 2 scores were associated with hip effusion-synovitis. Greater scores for mode 2 (decreasing acetabular coverage) and lower mode 4 (non-spherical femoral head) at baseline predicted 10-year total hip replacement (THR); while mode 4 alone correlated with bone marrow lesions (BMLs), effusion-synovitis, and increased cartilage signal.Conclusions: Hip shape is associated with ROA, THR, hip pain, effusion-synovitis, BMLs, muscle strength and hip structural changes. These data suggest that different shape modes reflect multiple facets of hip osteoarthritis. This article is protected by copyright. All rights reserved.

AB - Objective: Hip morphology plays a significant role in the incidence and progression of hip osteoarthritis (OA). We hypothesized that hip shape would also associate with other key factors and tested this in a longitudinal community-based cohort combining radiographic, MRI, DXA, and clinical data.Methods: Baseline dual-energy X-ray absorptiometry (DXA) images of the left hip of 831 subjects from the Tasmanian Older Adult Cohort (TASOAC) were analyzed using an 85-point statistical shape model. Hip pain was assessed by WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index) and muscle strength was measured by a dynamometer. Hip structural changes were assessed using MRI and Radiographic OA (ROA) using plain radiographs.Results: Six shape modes described 68% of shape variation. At baseline, modes 1, 2, 4 and 6 were associated with hip ROA, modes 1, 3, 4 and 6 correlated with hip cartilage volume and all except mode 2 with muscle strength. Higher mode 1, and lower mode 3 and 6 scores at baseline predicted hip pain at follow-up and higher mode 1 and mode 2 scores were associated with hip effusion-synovitis. Greater scores for mode 2 (decreasing acetabular coverage) and lower mode 4 (non-spherical femoral head) at baseline predicted 10-year total hip replacement (THR); while mode 4 alone correlated with bone marrow lesions (BMLs), effusion-synovitis, and increased cartilage signal.Conclusions: Hip shape is associated with ROA, THR, hip pain, effusion-synovitis, BMLs, muscle strength and hip structural changes. These data suggest that different shape modes reflect multiple facets of hip osteoarthritis. This article is protected by copyright. All rights reserved.

U2 - 10.1002/acr.23166

DO - 10.1002/acr.23166

M3 - Article

SN - 0893-7524

VL - 69

SP - 1566

EP - 1573

JO - Arthritis Care & Research

JF - Arthritis Care & Research

IS - 10

ER -

Hip Shape as a Predictor of Osteoarthritis Progression in a Prospective Population Cohort

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