HPLC-HG-ICP-MS: a sensitive and selective method for inorganic arsenic in seafood

Asta H. Petursdottir, Helga Gunnlaugsdottir, Hroenn Joerundsdottir, Adrien Mestrot, Eva M. Krupp, Joerg Feldmann

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)


The addition of an online post-column hydride generation (HG) step to the commonly used high-performance liquid chromatography inductively coupled plasma-mass spectrometry (HPLC-ICP-MS) setup for arsenic speciation proved to significantly improve the detection limits for the determination of inorganic arsenic (iAs) as arsenate in seafood samples, where the limit of detection and limit of quantification were found to be 0.0004 and 0.0014 mg kg(-1), respectively with HG. HG as an additional step further added to the selectivity of the determination of the iAs species and increased the detection and quantification of low levels of iAs (< 0.002 mg kg(-1)) in samples with complicated matrices.

Original languageEnglish
Pages (from-to)2185-2191
Number of pages7
JournalAnalytical and Bioanalytical Chemistry
Issue number8
Publication statusPublished - Nov 2012


  • speciation
  • analytical chemistry
  • seafood
  • arsenic
  • inorganic
  • CRM
  • feed
  • fish meal


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