Human skeletal muscle myosin function at physiological and non-physiological temperatures

Arimantas Lionikas, M Li, L Larsson

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


AIM: The aim of the study was to assess the function of human skeletal muscle myosin across a wide range of temperatures, including physiological. METHODS: We used a single fibre in vitro motility assay. The in vitro motility speed of actin filaments propelled by myosin extracted from fibres expressing type I myosin heavy chain (MyHC; n = 9), IIa MyHC (n = 6), IIax MyHC (n = 4) and I/IIa MyHC (n = 1) was measured at 15, 20, 25, 30 and 35 degrees C. RESULTS: The motility speed between groups of fibres expressing different MyHC differed significantly (P
Original languageEnglish
Pages (from-to)151-158
Number of pages8
JournalActa Physiologica
Issue number2
Early online date22 Dec 2005
Publication statusPublished - 1 Feb 2006


  • Adult
  • Animals
  • Electrophoresis, Polyacrylamide Gel
  • Humans
  • Male
  • Microfilaments
  • Muscle Contraction
  • Muscle Fibers, Skeletal
  • Muscle, Skeletal
  • Protein Isoforms
  • Rabbits
  • Skeletal Muscle Myosins
  • Temperature


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