Hyperthyroidism differentially regulates neuropeptide S system in the rat brain

Carmen R González, Pablo B Martínez de Morentin, Noelia Martínez-Sánchez, Consuelo Gómez-Díaz, Ricardo Lage, Luis Varela, Carlos Diéguez, Rubén Nogueiras, Justo P Castaño, Miguel López

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


Thyroid hormones play an important role in the regulation of energy balance, sleep and emotional behaviors. Neuropeptide S (NPS) is a recently discovered neuropeptide, regulating feeding, sleep and anxiety. Here, we examined the effect of hyperthyroidism on the gene and protein expression of neuropeptide S and its receptor (NPS-R) in the hypothalamus, brainstem and amygdala of rats. Our results showed that the expression of NPS and NPS-R was differentially modulated by hyperthyroidism in the rat brain. NPS and NPS-R mRNA and protein levels were decreased in the hypothalamus of hyperthyroid rats. Conversely NPS-R expression was highly increased in the brainstem and NPS and NPS-R expression were unchanged in the amygdala of these rats. These data suggest that changes in anxiety and food intake patterns observed in hyperthyroidism could be associated with changes in the expression of NPS and NPS-R. Thus, the NPS/NPS-R system may be involved in several hyperthyroidism-associated comorbidities.

Original languageEnglish
Pages (from-to)40-48
Number of pages9
JournalBrain Research
Early online date18 Feb 2012
Publication statusPublished - 23 Apr 2012

Bibliographical note

We sincerely thank to Dr. Andrew Whittle (University of Cambridge) for his comments, suggestions and criticism. The research leading to these results has received funding from the European Community's Seventh Framework Programme (FP7/2007-2013) under grant agreement n° 281854– the ObERStress project (ML), 245009– the Neurofast project (RN, CD and ML), and 223713 (CD, RN, ML), Fondo Investigationes Sanitarias (ML: PS09/01880), Ministerio de Educaciony Ciencia (RN: RyC-2008-02219; JPC: BFU2010-19300; ML: RyC-2007-00211), Junta de Andalucía (JPC: BIO-139 and CTS-5051),Ministerio de Ciencia e Innovación (RN: SAF2009-07049), and Xunta de Galicia (RN 2010/14 and ML: 10PXIB208164PR).CIBER de Fisiopatología de la Obesidad y Nutrición is an initiative of ISCIII. Authors declare no conflict of interest.


  • Amygdala
  • Animals
  • Brain Stem
  • Eating
  • Gene Expression
  • Hyperthyroidism
  • Hypothalamus
  • Male
  • Neuropeptides
  • Rats
  • Rats, Sprague-Dawley
  • Sleep


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