Hyposplenism and gastrointestinal diseases: significance and mechanisms

Abhinav Mathur* (Corresponding Author), Mairi H McLean, Huan Cao, Mark A Vickers

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

5 Citations (Scopus)
3 Downloads (Pure)


Background: Functional hyposplenism is a recognized complication of several gastroenterological disorders, including coeliac and inflammatory bowel diseases, and is believed to contribute to the increased infection risk seen in these disorders. Summary: The mechanisms of hyposplenism are poorly understood. In this article, we review possible mechanisms underlying development of functional hyposplenism and discuss implications for its management. Key Messages: Identifying functional hyposplenism is important, as it may permit earlier recognition and treatment of serious infections through patient education and vaccination.
Original languageEnglish
Pages (from-to)290–298
Number of pages9
JournalDigestive Diseases
Early online date31 May 2021
Publication statusPublished - May 2022

Bibliographical note

Open Access via the Karger Agreement

This work was funded in part by Wellcome Trust Grant number 0934847/Z/10/Z.


  • hyposplenism
  • spleen
  • coeliac disease
  • inflammatory bowel disease


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