Hypothetical model ignores many important pathophysiologic mechanisms in fibromyalgia

Daniel J Clauw; Ernest H S Choy; Vitaly Napadow; Anushka Soni; Kevin F Boehnke; Bruce Naliboff; Afton L Hassett; Anne Arewasikporn; Andrew Schrepf; Chelsea M Kaplan; David Williams; Neil Basu; Rachel S Bergmans; Richard E Harris; Steven E Harte; Andrea Chadwick; Gary J Macfarlane

doi:10.1038/s41584-023-00951-3

Hypothetical model ignores many important pathophysiologic mechanisms in fibromyalgia

Daniel J Clauw^* (Corresponding Author), Ernest H S Choy, Vitaly Napadow, Anushka Soni, Kevin F Boehnke, Bruce Naliboff, Afton L Hassett, Anne Arewasikporn, Andrew Schrepf, Chelsea M Kaplan, David Williams, Neil Basu, Rachel S Bergmans, Richard E Harris, Steven E Harte, Andrea Chadwick, Gary J Macfarlane

^*Corresponding author for this work

Research output: Contribution to journal › Comment/debate › peer-review

2 Citations (Scopus)

Abstract

We would like to respond to the Perspective article by Pinto et al. (Pinto, A. M. et al. Emotion regulation and the salience network: a hypothetical integrative model of fibromyalgia. Nat. Rev. Rheumatol. 19, 44–60 (2023))1. We feel that the proposed model severely overfits the complicated pathophysiology of fibromyalgia and is not applicable to all or even most individuals with this condition. We are concerned that this theory could inadvertently drive the field backwards despite several decades of research that has begun to illuminate neurobiological mechanisms underlying fibromyalgia and other chronic pain conditions. Our main points are outlined here.

Original language	English
Pages (from-to)	321
Number of pages	1
Journal	Nature Reviews Rheumatology
Volume	19
Early online date	24 Mar 2023
DOIs	https://doi.org/10.1038/s41584-023-00951-3
Publication status	Published - May 2023

Bibliographical note

There is a reply to this letter by Pinto et al. Nat. Rev. Rheumatol. https://doi.org/10.1038/s41584-023-00952-2 (2023).

Keywords

Chronic pain
somatosensory system

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Clauw, D. J., Choy, E. H. S., Napadow, V., Soni, A., Boehnke, K. F., Naliboff, B., Hassett, A. L., Arewasikporn, A., Schrepf, A., Kaplan, C. M., Williams, D., Basu, N., Bergmans, R. S., Harris, R. E., Harte, S. E., Chadwick, A., & Macfarlane, G. J. (2023). Hypothetical model ignores many important pathophysiologic mechanisms in fibromyalgia. Nature Reviews Rheumatology, 19, 321. https://doi.org/10.1038/s41584-023-00951-3

Clauw, DJ, Choy, EHS, Napadow, V, Soni, A, Boehnke, KF, Naliboff, B, Hassett, AL, Arewasikporn, A, Schrepf, A, Kaplan, CM, Williams, D, Basu, N, Bergmans, RS, Harris, RE, Harte, SE, Chadwick, A & Macfarlane, GJ 2023, 'Hypothetical model ignores many important pathophysiologic mechanisms in fibromyalgia', Nature Reviews Rheumatology, vol. 19, pp. 321. https://doi.org/10.1038/s41584-023-00951-3

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title = "Hypothetical model ignores many important pathophysiologic mechanisms in fibromyalgia",

abstract = "We would like to respond to the Perspective article by Pinto et al. (Pinto, A. M. et al. Emotion regulation and the salience network: a hypothetical integrative model of fibromyalgia. Nat. Rev. Rheumatol. 19, 44–60 (2023))1. We feel that the proposed model severely overfits the complicated pathophysiology of fibromyalgia and is not applicable to all or even most individuals with this condition. We are concerned that this theory could inadvertently drive the field backwards despite several decades of research that has begun to illuminate neurobiological mechanisms underlying fibromyalgia and other chronic pain conditions. Our main points are outlined here.",

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note = "There is a reply to this letter by Pinto et al. Nat. Rev. Rheumatol. https://doi.org/10.1038/s41584-023-00952-2 (2023).",

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AU - Naliboff, Bruce

AU - Hassett, Afton L

AU - Arewasikporn, Anne

AU - Schrepf, Andrew

AU - Kaplan, Chelsea M

AU - Williams, David

AU - Basu, Neil

AU - Bergmans, Rachel S

AU - Harris, Richard E

AU - Harte, Steven E

AU - Chadwick, Andrea

AU - Macfarlane, Gary J

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AB - We would like to respond to the Perspective article by Pinto et al. (Pinto, A. M. et al. Emotion regulation and the salience network: a hypothetical integrative model of fibromyalgia. Nat. Rev. Rheumatol. 19, 44–60 (2023))1. We feel that the proposed model severely overfits the complicated pathophysiology of fibromyalgia and is not applicable to all or even most individuals with this condition. We are concerned that this theory could inadvertently drive the field backwards despite several decades of research that has begun to illuminate neurobiological mechanisms underlying fibromyalgia and other chronic pain conditions. Our main points are outlined here.

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ER -

Hypothetical model ignores many important pathophysiologic mechanisms in fibromyalgia

Abstract

Bibliographical note

Keywords

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