Candida albicans: a shape changing, opportunistic pathogenic fungus of humans

Neil A. R. Gow* (Corresponding Author), Bhawna Yadav

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

95 Citations (Scopus)
14 Downloads (Pure)

Abstract

Candida albicans is normally a harmless commensal of human beings, but it can cause superficial infections of the mucosa (oral/vaginal thrush) in healthy individuals and (rarely) infections of the skin or nails. It can also become invasive, causing life-threatening systemic and bloodstream infections in immunocompromised hosts, where the mortality rate can be as high as 50 %. It is the most common cause of serious fungal infection and is a common cause of nosocomial infections in hospitals. Some strains have been recognized that are resistant to azoles or echinocandins, which are the first-line antifungals for treatment of C. albicans infections.
Original languageEnglish
Pages (from-to)1145-1147
Number of pages3
JournalMicrobiology
Volume163
Issue number8
Early online date15 Aug 2017
DOIs
Publication statusPublished - Aug 2017

Bibliographical note

Funding information
The authors received funding support from Wellcome Trust (086827, 075470, 101873 and 200208) and the MRC Centre for Medical Mycology (N006364/1).

Acknowledgements
We thank Prashant Sood for help with the graphical abstract figure.

Keywords

  • immune response
  • drug resistance
  • candida albicans
  • pathogenesis
  • morphogenesis
  • medical mycology

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