IL-15-secreting γδT cells induce memory T cells in experimental allergic encephalomyelitis (EAE) mice

Xiaoqian Wang, Yinxiang Wei, Xiaoling Liu, Chen Xing, Gencheng Han, Guojiang Chen, Chunmei Hou, Ivy M. Dambuza, Beifen Shen, Yan Li, He Xiao (Corresponding Author), Renxi Wang (Corresponding Author)

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


With the most recent data suggesting γδT cells as primary producers of the pro-inflammatory autoimmune-associated cytokine, the relationship between γδT cells and Th17 in experimental allergic encephalitis (EAE) mice requires more extensive investigation. By flow cytometry and qPCR, we identified a new subset of IL-15-secreting γδT (γδT15) cells that increased in EAE mice. The capacity of IL-15-secreting γδT cells inducing memory T cells and memory T cells inducing IL-17(+)Th17 was examined by transferring into EAE mice and 7-week-old female nude mice, respectively. We found that γδT15 induced CD44(hi) memory T cells by secreting IL-15. γδT15-induced memory T cells induced EAE by transforming into pathogenic Th17 cells. The data suggest that a new subset of IL-15-secreting γδT cells mediated the production of memory T cells which transformed into pathogenic Th17 cells in EAE mice.

Original languageEnglish
Pages (from-to)402-408
Number of pages7
JournalMolecular Immunology
Issue number2
Early online date18 May 2015
Publication statusPublished - Aug 2015

Bibliographical note

This study was supported by National Natural Science Foundation of China (81471529, 81272320 and 81172800), Beijing Natural Science Foundation (7132139, 7141007 and 7132151) and National Basic Research Program 973 Grants (2013CB530506).


  • Multiple sclerosis
  • EAE
  • γδT Cells
  • IL-15
  • Th17


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