IL-17 and neutrophils: unexpected players in the type 2 immune response.

Judith E Allen, Tara Sutherland, Dominik Ruckerl

Research output: Contribution to journalArticlepeer-review

61 Citations (Scopus)

Abstract

The study of immunity to helminth infection has been central to understanding the function of type 2 cytokines and their targets. Although type 2 cytokines are considered anti-inflammatory and promote tissue repair, they also contribute to allergy and fibrosis. Here, we utilise data from helminth infection models, to illustrate that IL-17 and neutrophils, typically associated with pro-inflammatory responses, are intimately linked with type 2 immunity. Neutrophils work with IL-4Rα-activated macrophages to control incoming larvae but this comes at a cost of enhanced tissue damage. Chitinase like proteins (CLPs) bridge these diverse outcomes, inducing both protective IL-17 and reparative Th2 responses. Dysregulation of CLPs, IL-17 and neutrophils likely contribute to disease severity and pathology associated with type 2 immunity.
Original languageEnglish
Pages (from-to)99-106
JournalCurrent Opinion in Immunology
Volume34
DOIs
Publication statusPublished - 1 Jun 2015

Bibliographical note

095831MA, Wellcome Trust, United Kingdom
MR/J001929/1, Medical Research Council, United Kingdom
MR/K01207X/1, Medical Research Council, United Kingdom

Acknowledgements
The authors are supported by funding from the Medical Research Council UK (MR/J001929/1, MR/K01207X/1) and the Wellcome Trust funded Centre for Immunity, Infection and Evolution (095831MA).

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