Immune Recognition of Candida albicans ß-glucan by Dectin-1

Neil A. R. Gow, Mihai G. Netea, Carol A. Munro, Gerben Ferwerda, Steven Bates, Héctor M. Mora-Montes, Louise Walker, Trees Jansen, Liesbeth Jacobs, Vicky Tsoni, Gordon D. Brown, Frank C. Odds, Jos W. M. Van der Meer, Alistair J. P. Brown, Bart Jan Kullberg

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243 Citations (Scopus)


Beta (1,3)-glucans represent 40% of the cell wall of the yeast Candida albicans. The dectin-1 lectin-like receptor has shown to recognize fungal beta (1,3)-glucans and induce innate immune responses. The importance of beta-glucan-dectin-1 pathways for the recognition of C. albicans by human primary blood cells has not been firmly established. In this study we demonstrate that cytokine production by both human peripheral blood mononuclear cells and murine macrophages is dependent on the recognition of beta-glucans by dectin-1. Heat killing of C. albicans resulted in exposure of beta-glucans on the surface of the cell wall and subsequent recognition by dectin-1, whereas live yeasts stimulated monocytes mainly via recognition of cell-surface mannans. Dectin-1 induced cytokine production through the following 2 pathways: Syk-dependent production of the T-helper (Th) 2-type anti-inflammatory cytokine interleukin-10 and Toll-like receptor-Myd88-dependent stimulation of monocyte-derived proinflammatory cytokines, such as tumor necrosis factor-alpha . In contrast, stimulation of Th1-type cytokines, such as interferon-gamma , by C. albicans was independent of the recognition of beta-glucans by dectin-1. In conclusion, C. albicans induces production of monocyte-derived and T cell-derived cytokines through distinct pathways dependent on or independent of dectin-1.
Original languageEnglish
Pages (from-to)1565-1571
Number of pages7
JournalThe journal of infectious diseases
Issue number10
Publication statusPublished - 15 Nov 2007


  • animals
  • candida albicans
  • candidiasis
  • disease models, animal
  • humans
  • leukocytes, mononuclear
  • macrophages, peritoneal
  • membrane proteins
  • mice
  • mice, knockout
  • nerve tissue proteins
  • receptors, immunologic


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