Immunology of Gut-Bone Signaling

Fraser L Collins, Jonathan D Schepper, Naiomy Deliz Rios-Arce, Michael D Steury, Ho Jun Kang, Heather Mallin, Daniel Schoenherr, Glen Camfield, Saima Chishti, Laura R McCabe, Narayanan Parameswaran

Research output: Chapter in Book/Report/Conference proceedingChapter

17 Citations (Scopus)


In recent years a link between the gastrointestinal tract and bone health has started to gain significant attention. Dysbiosis of the intestinal microbiota has been linked to the pathology of a number of diseases which are associated with bone loss. In addition modulation of the intestinal microbiota with probiotic bacteria has revealed to have both beneficial local and systemic effects. In the present chapter, we discuss the intestinal and bone immune systems, explore how intestinal disease affects the immune system, and examine how these pathologic changes could adversely impact bone health.

Original languageEnglish
Title of host publicationUnderstanding the Gut-Bone Signaling Axis
Subtitle of host publicationMechanisms and Therapeutic Implications
EditorsLaura R McCabe, Narayanan Parameswaran
Place of PublicationCham
Number of pages36
ISBN (Electronic)978-3-319-66653-2
ISBN (Print)978-3-319-66651-8
Publication statusPublished - 2017

Publication series

NameAdvances in Experimental Medicine and Biology
PublisherSpringer New York
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019


  • Animals
  • Bone Remodeling/immunology
  • Bone and Bones/cytology
  • Cytokines/immunology
  • Gastrointestinal Tract/cytology
  • Humans
  • Immune System/cytology
  • Intestinal Diseases/immunology
  • Lymphocytes/immunology
  • Signal Transduction/immunology


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