Abstract
Neurodevelopmental delay is associated with neurodevelopmental disorders. Prenatal metal exposure can potentially cause neurodevelopmental delays in children. This study examines whether prenatal exposure to mercury (Hg) and selenium (Se) is associated with the risk of neurodevelopmental delays in children up to 4 years of age. Children enrolled in a prospective birth cohort of the Japan Environment and Children's Study were examined. Hg and Se levels in maternal (n(child) = 48,731) and cord (n(child) = 3,083) blood were analyzed by inductively coupled plasma-mass spectrometry. Neurodevelopmental delays were assessed in children between the ages of 0.5 to 4 years using the Ages and Stages Questionnaires, Third Edition. The association between exposure and outcomes was examined using the generalized estimation equation models. In maternal blood, compared to participants with Se levels in the first quartile (83.0 to
Original language | English |
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Article number | 107448 |
Number of pages | 10 |
Journal | Environment International |
Volume | 168 |
Early online date | 4 Aug 2022 |
DOIs | |
Publication status | Published - 1 Oct 2022 |
Bibliographical note
AcknowledgmentsWe thank the participants and their children in the JECS. We wish to express our sincere appreciation to the collaborating hospitals and clinics. We also express our gratitude to all the JECS staff members in Hokkaido, Miyagi, Fukushima, Chiba, Kanagawa, Koshin, Toyama, Aichi, Kyoto, Osaka, Hyogo, Tottori, Kochi, Fukuoka, and MinamiKyushu and Okinawa regional centers and national center for JECS (Programme Office), and the Medical Support Center (Appendix 1).
Funding
This study was funded by the Ministry of the Environment, Japan. The findings and conclusion of this article are solely the responsibility of the authors and do not represent the official views of the above government.
Keywords
- Ages and Stages Questionnaires
- Japan Environment and Children’s Study
- Mercury
- Neurodevelopment
- Pregnancy
- Selenium