Importance of the Candida albicans cell wall during commensalism and infection

N.A.R. Gow, B. Hube

Research output: Contribution to journalArticlepeer-review

248 Citations (Scopus)
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An imbalance of the normal microbial flora, breakage of epithelial barriers or dysfunction of the immune system favour the transition of the human pathogenic yeast Candida albicans from a commensal to a pathogen. C. albicans has evolved to be adapted as a commensal on mucosal surfaces. As a commensal it has also acquired attributes, which are necessary to avoid or overcome the host defence mechanisms. The human host has also co-evolved to recognize and eliminate potential fungal invaders. Many of the fungal genes that have been the focus of this co-evolutionary process encode cell wall components. In this review, we will discuss the transition from commensalism to pathogenesis, the key players of the fungal cell surface that are important for this transition, the role of the morphology and the mechanisms of host recognition and response.

Original languageEnglish
Pages (from-to)406-412
Number of pages7
JournalCurrent Opinion in Microbiology
Issue number4
Early online date18 May 2012
Publication statusPublished - Aug 2012


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