Abstract
Tritium-labelled fluoroazomycin arabinoside, [3H]-FAZA, is a useful probe for the investigation of hypoxia, furthermore it is safer and easier to handle than the PET tracer [18F]-FAZA when used in cell based assays. The only known synthesis of deuterium- and tritium-labelled FAZA was re-investigated and optimized. Then, a new and improved synthesis of [2H]-FAZA was developed as a model process for tritium radiolabelling. This novel synthesis is expected to greatly facilitate access to [3H]-FAZA.
Original language | English |
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Pages (from-to) | 110-117 |
Number of pages | 8 |
Journal | Journal of Fluorine Chemistry |
Volume | 155 |
Early online date | 29 Jun 2013 |
DOIs | |
Publication status | Published - Nov 2013 |
Keywords
- hypoxia
- PET imaging
- deuterium
- tritium
- FAZA