Improving Adherence to Medication in stroke Survivors (IAMSS): a randomised controlled trial: study protocol

Ronan O'Carroll, Martin Dennis, Marie Johnston, Cathie Sudlow

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28 Citations (Scopus)
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Adherence to therapies is a primary determinant of treatment success, yet the World Health Organisation estimate that only 50% of patients who suffer from chronic diseases adhere to treatment recommendations. In a previous project, we found that 30% of stroke patients reported sub-optimal medication adherence, and this was associated with younger age, greater cognitive impairment, lower perceptions of medication benefits and higher specific concerns about medication. We now wish to pilot a brief intervention aimed at (a) helping patients establish a better medication-taking routine, and (b) eliciting and modifying any erroneous beliefs regarding their medication and their stroke.

Thirty patients will be allocated to a brief intervention (2 sessions) and 30 to treatment as usual. The primary outcome will be adherence measured over 3 months using Medication Event Monitoring System (MEMS) pill containers which electronically record openings. Secondary outcomes will include self reported adherence and blood pressure.

This study shall also assess uptake/attrition, feasibility, ease of understanding and acceptability of this complex intervention.

Trial Registration
Current Controlled Trials ISRCTN38274953

Original languageEnglish
Article number15
Number of pages9
JournalBMC Neurology
Publication statusPublished - 24 Feb 2010


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