Infant arterial stiffness and maternal iron status in pregnancy: a UK birth cohort (Baby VIP study)

Nisreen A Alwan; Janet E Cade; Harry J McArdle; Darren C Greenwood; Helen E Hayes; Etienne Ciantar; Nigel A B Simpson

doi:10.1159/000377618

Infant arterial stiffness and maternal iron status in pregnancy: a UK birth cohort (Baby VIP study)

Nisreen A Alwan, Janet E Cade, Harry J McArdle, Darren C Greenwood, Helen E Hayes, Etienne Ciantar, Nigel A B Simpson

The Rowett Institute of Nutrition and Health

University of Leeds

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

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Abstract

BACKGROUND: In animal studies, iron deficiency during pregnancy has been linked to increased offspring cardiovascular risk. No previous population studies have measured arterial stiffness early in life to examine its association with maternal iron status.

OBJECTIVE: This study aimed to examine the association between maternal iron status in early pregnancy with infant brachio-femoral pulse wave velocity (PWV).

METHODS: The Baby VIP (Baby's Vascular Health and Iron in Pregnancy) study is a UK-based birth cohort which recruited 362 women after delivery from the Leeds Teaching Hospitals postnatal wards. Ferritin and transferrin receptor levels were measured in maternal serum samples previously obtained in the first trimester. Infant brachio-femoral PWV was measured during a home visit at 2-6 weeks.

RESULTS: Iron depletion (ferritin <15 μg/l) was detected in 79 (23%) women in early pregnancy. Infant PWV (mean = 6.7 m/s, SD = 1.3, n = 284) was neither associated with maternal ferritin (adjusted change per 10 μg/l = 0.02, 95% CI: -0.01, 0.1), nor with iron depletion (adjusted change = -0.2, 95% CI: -0.6, 0.2). No evidence of association was observed between maternal serum transferrin receptor level and its ratio to ferritin with infant PWV. Maternal anaemia (<11 g/dl) at ≤20 weeks' gestation was associated with a 1.0-m/s increase in infant PWV (adjusted 95% CI: 0.1, 1.9).

CONCLUSION: This is the largest study to date which has assessed peripheral PWV as a measure of arterial stiffness in infants. There was no evidence of an association between markers of maternal iron status early in pregnancy and infant PWV. © 2015 S. Karger AG, Basel.

Original language	English
Pages (from-to)	297-303
Number of pages	7
Journal	Neonatology
Volume	107
Issue number	4
Early online date	12 Mar 2015
DOIs	https://doi.org/10.1159/000377618
Publication status	Published - Jun 2015

Bibliographical note

Acknowledgements
We are sincerely grateful to all study participants. Our thanks go to Angela Wray, Julie Grindey and Viv Dolby for data collection; Antony Hales, Russel Booth, Ruth Owen and Christine Kennedy for facilitating laboratory analysis, and Stephen Greenwald for advice on PWV measurement. Source of funding: N.A.A. is funded by a Wellcome Trust Research Training Fellowship (WT87789). H.J.M. and H.E.H. are supported by the Scottish Government Rural and Environmental Services (RESAS). N.A.B.S. is supported by Cerebra.

Keywords

vascular stiffness
iron
pregnancy
infant
micronutrients
anaemia

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10.1159/000377618Licence: CC BY

Infant Arterial Stiffness and Maternal Iron Status in Pregnancy
Open Access License: This is an Open Access article licensed under the terms of the Creative Commons Attribution 3.0 Unported license (CC BY 3.0), applicable to the online version of the article only. http://creativecommons.org/licenses/by/3.0/
Final published version, 487 KBLicence: CC BY

Cite this

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title = "Infant arterial stiffness and maternal iron status in pregnancy: a UK birth cohort (Baby VIP study)",

abstract = "BACKGROUND: In animal studies, iron deficiency during pregnancy has been linked to increased offspring cardiovascular risk. No previous population studies have measured arterial stiffness early in life to examine its association with maternal iron status.OBJECTIVE: This study aimed to examine the association between maternal iron status in early pregnancy with infant brachio-femoral pulse wave velocity (PWV).METHODS: The Baby VIP (Baby's Vascular Health and Iron in Pregnancy) study is a UK-based birth cohort which recruited 362 women after delivery from the Leeds Teaching Hospitals postnatal wards. Ferritin and transferrin receptor levels were measured in maternal serum samples previously obtained in the first trimester. Infant brachio-femoral PWV was measured during a home visit at 2-6 weeks.RESULTS: Iron depletion (ferritin <15 μg/l) was detected in 79 (23%) women in early pregnancy. Infant PWV (mean = 6.7 m/s, SD = 1.3, n = 284) was neither associated with maternal ferritin (adjusted change per 10 μg/l = 0.02, 95% CI: -0.01, 0.1), nor with iron depletion (adjusted change = -0.2, 95% CI: -0.6, 0.2). No evidence of association was observed between maternal serum transferrin receptor level and its ratio to ferritin with infant PWV. Maternal anaemia (<11 g/dl) at ≤20 weeks' gestation was associated with a 1.0-m/s increase in infant PWV (adjusted 95% CI: 0.1, 1.9).CONCLUSION: This is the largest study to date which has assessed peripheral PWV as a measure of arterial stiffness in infants. There was no evidence of an association between markers of maternal iron status early in pregnancy and infant PWV. {\textcopyright} 2015 S. Karger AG, Basel.",

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author = "Alwan, {Nisreen A} and Cade, {Janet E} and McArdle, {Harry J} and Greenwood, {Darren C} and Hayes, {Helen E} and Etienne Ciantar and Simpson, {Nigel A B}",

note = "Acknowledgements We are sincerely grateful to all study participants. Our thanks go to Angela Wray, Julie Grindey and Viv Dolby for data collection; Antony Hales, Russel Booth, Ruth Owen and Christine Kennedy for facilitating laboratory analysis, and Stephen Greenwald for advice on PWV measurement. Source of funding: N.A.A. is funded by a Wellcome Trust Research Training Fellowship (WT87789). H.J.M. and H.E.H. are supported by the Scottish Government Rural and Environmental Services (RESAS). N.A.B.S. is supported by Cerebra. ",

year = "2015",

month = jun,

doi = "10.1159/000377618",

language = "English",

volume = "107",

pages = "297--303",

journal = "Neonatology",

issn = "1661-7800",

publisher = "S. Karger AG",

number = "4",

}

TY - JOUR

T1 - Infant arterial stiffness and maternal iron status in pregnancy

T2 - a UK birth cohort (Baby VIP study)

AU - Alwan, Nisreen A

AU - Cade, Janet E

AU - McArdle, Harry J

AU - Greenwood, Darren C

AU - Hayes, Helen E

AU - Ciantar, Etienne

AU - Simpson, Nigel A B

N1 - Acknowledgements We are sincerely grateful to all study participants. Our thanks go to Angela Wray, Julie Grindey and Viv Dolby for data collection; Antony Hales, Russel Booth, Ruth Owen and Christine Kennedy for facilitating laboratory analysis, and Stephen Greenwald for advice on PWV measurement. Source of funding: N.A.A. is funded by a Wellcome Trust Research Training Fellowship (WT87789). H.J.M. and H.E.H. are supported by the Scottish Government Rural and Environmental Services (RESAS). N.A.B.S. is supported by Cerebra.

PY - 2015/6

Y1 - 2015/6

N2 - BACKGROUND: In animal studies, iron deficiency during pregnancy has been linked to increased offspring cardiovascular risk. No previous population studies have measured arterial stiffness early in life to examine its association with maternal iron status.OBJECTIVE: This study aimed to examine the association between maternal iron status in early pregnancy with infant brachio-femoral pulse wave velocity (PWV).METHODS: The Baby VIP (Baby's Vascular Health and Iron in Pregnancy) study is a UK-based birth cohort which recruited 362 women after delivery from the Leeds Teaching Hospitals postnatal wards. Ferritin and transferrin receptor levels were measured in maternal serum samples previously obtained in the first trimester. Infant brachio-femoral PWV was measured during a home visit at 2-6 weeks.RESULTS: Iron depletion (ferritin <15 μg/l) was detected in 79 (23%) women in early pregnancy. Infant PWV (mean = 6.7 m/s, SD = 1.3, n = 284) was neither associated with maternal ferritin (adjusted change per 10 μg/l = 0.02, 95% CI: -0.01, 0.1), nor with iron depletion (adjusted change = -0.2, 95% CI: -0.6, 0.2). No evidence of association was observed between maternal serum transferrin receptor level and its ratio to ferritin with infant PWV. Maternal anaemia (<11 g/dl) at ≤20 weeks' gestation was associated with a 1.0-m/s increase in infant PWV (adjusted 95% CI: 0.1, 1.9).CONCLUSION: This is the largest study to date which has assessed peripheral PWV as a measure of arterial stiffness in infants. There was no evidence of an association between markers of maternal iron status early in pregnancy and infant PWV. © 2015 S. Karger AG, Basel.

AB - BACKGROUND: In animal studies, iron deficiency during pregnancy has been linked to increased offspring cardiovascular risk. No previous population studies have measured arterial stiffness early in life to examine its association with maternal iron status.OBJECTIVE: This study aimed to examine the association between maternal iron status in early pregnancy with infant brachio-femoral pulse wave velocity (PWV).METHODS: The Baby VIP (Baby's Vascular Health and Iron in Pregnancy) study is a UK-based birth cohort which recruited 362 women after delivery from the Leeds Teaching Hospitals postnatal wards. Ferritin and transferrin receptor levels were measured in maternal serum samples previously obtained in the first trimester. Infant brachio-femoral PWV was measured during a home visit at 2-6 weeks.RESULTS: Iron depletion (ferritin <15 μg/l) was detected in 79 (23%) women in early pregnancy. Infant PWV (mean = 6.7 m/s, SD = 1.3, n = 284) was neither associated with maternal ferritin (adjusted change per 10 μg/l = 0.02, 95% CI: -0.01, 0.1), nor with iron depletion (adjusted change = -0.2, 95% CI: -0.6, 0.2). No evidence of association was observed between maternal serum transferrin receptor level and its ratio to ferritin with infant PWV. Maternal anaemia (<11 g/dl) at ≤20 weeks' gestation was associated with a 1.0-m/s increase in infant PWV (adjusted 95% CI: 0.1, 1.9).CONCLUSION: This is the largest study to date which has assessed peripheral PWV as a measure of arterial stiffness in infants. There was no evidence of an association between markers of maternal iron status early in pregnancy and infant PWV. © 2015 S. Karger AG, Basel.

KW - vascular stiffness

KW - iron

KW - pregnancy

KW - infant

KW - micronutrients

KW - anaemia

U2 - 10.1159/000377618

DO - 10.1159/000377618

M3 - Article

C2 - 25790854

SN - 1661-7800

VL - 107

SP - 297

EP - 303

JO - Neonatology

JF - Neonatology

IS - 4

ER -

Infant arterial stiffness and maternal iron status in pregnancy: a UK birth cohort (Baby VIP study)

Abstract

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Keywords

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