Abstract
Background
Previous evidence suggests that placental dysfunction including pre-eclampsia is inherited from mother to daughter, but heritability of stillbirth has never been investigated.
Objective
To investigate if there is an inherited predisposition to stillbirth transmitted from mother to daughter.
Study Design
We carried out a nested case-control study within the intergenerational cohort held in the Aberdeen Maternity and Neonatal Databank (AMND). All mothers who had at least one daughter in Aberdeen, United Kingdom between 1949 and 2000 were included. Mother – daughter pairs were linked using the Scottish Community Health Index (CHI) number. The main exposure was mother’s history of stillbirth. The primary outcome was stillbirth in any of the daughter’s pregnancies. A population average model using Generalised Estimating Equations (GEE) with robust standard errors was used to estimate odds of a mother’s history of stillbirth in daughters with a stillbirth compared to daughters with only livebirths. This method accounted for clustering of daughters within mothers and multi-adjusted analyses were performed to include confounders at the daughter’s pregnancy level.
Results
Among the daughters, 384 had a history of one or more stillbirths (cases) while 26,404 only ever had livebirths (controls). We found no statistically significant association between mothers’ history of stillbirth (adjusted Odds Ratio (aOR) 0.63; 95% CI 0.24-1.63) or miscarriage (aOR 1.01; 95% CI 0.71-1.42) and stillbirth in daughters.
Conclusions
This is the first study to investigate an inherited predisposition to stillbirth. There was no evidence of an inherited predisposition to stillbirth transmitted from mother to daughter.
Previous evidence suggests that placental dysfunction including pre-eclampsia is inherited from mother to daughter, but heritability of stillbirth has never been investigated.
Objective
To investigate if there is an inherited predisposition to stillbirth transmitted from mother to daughter.
Study Design
We carried out a nested case-control study within the intergenerational cohort held in the Aberdeen Maternity and Neonatal Databank (AMND). All mothers who had at least one daughter in Aberdeen, United Kingdom between 1949 and 2000 were included. Mother – daughter pairs were linked using the Scottish Community Health Index (CHI) number. The main exposure was mother’s history of stillbirth. The primary outcome was stillbirth in any of the daughter’s pregnancies. A population average model using Generalised Estimating Equations (GEE) with robust standard errors was used to estimate odds of a mother’s history of stillbirth in daughters with a stillbirth compared to daughters with only livebirths. This method accounted for clustering of daughters within mothers and multi-adjusted analyses were performed to include confounders at the daughter’s pregnancy level.
Results
Among the daughters, 384 had a history of one or more stillbirths (cases) while 26,404 only ever had livebirths (controls). We found no statistically significant association between mothers’ history of stillbirth (adjusted Odds Ratio (aOR) 0.63; 95% CI 0.24-1.63) or miscarriage (aOR 1.01; 95% CI 0.71-1.42) and stillbirth in daughters.
Conclusions
This is the first study to investigate an inherited predisposition to stillbirth. There was no evidence of an inherited predisposition to stillbirth transmitted from mother to daughter.
Original language | English |
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Pages (from-to) | 393.e1-393.e7 |
Number of pages | 7 |
Journal | American Journal of Obstetrics and Gynecology |
Volume | 220 |
Issue number | 4 |
Early online date | 23 Jan 2019 |
DOIs | |
Publication status | Published - Apr 2019 |
Bibliographical note
Internal funding was received for the costs of data extraction from the Aberdeen Maternity and Neonatal Databank from the Fetal and Perinatal NHS Grampian endowment fund, NHS Grampian, Aberdeen, UK. No external funding was received.Keywords
- Stillbirth
- intrauterine death
- mother-daughter pairs
- family history
- familial
- intergenerational
- intrauterine
- stillbirth
- generalized estimating equations
- patterns
- death
- generations
- growth
- recurrence
- fetal
- birth
Fingerprint
Dive into the research topics of 'Inherited predisposition to stillbirth: an intergenerational analysis of 26,788 mother-daughter pairs'. Together they form a unique fingerprint.Datasets
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Aberdeen Maternity and Neonatal Databank
Bhattacharya, S. (Data Manager) & Wilde, K. J. (Supervisor), University of Aberdeen, 1986
http://www.abdn.ac.uk/iahs/research/obsgynae/amnd/overview.php and one more link, http://www.abdn.ac.uk/iahs/research/obsgynae/amnd/access.php (show fewer)
Dataset
Profiles
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Andrea Woolner
- School of Medicine, Medical Sciences & Nutrition, Applied Health Sciences - Clinical Senior Lecturer
- School of Medicine, Medical Sciences & Nutrition, Aberdeen Centre for Women’s Health Research
Person: Clinical Academic