Insulin is a Two-Edged Knife on the Brain

Susana Cardoso; Sonia Correia; Renato X Santos; Cristina Carvalho; Maria S Santos; Catarina R Oliveira; George  Perry; Mark A Smith; Xiongwei Zhu; Paula I Moreira

doi:10.3233/JAD-2009-1155

Insulin is a Two-Edged Knife on the Brain

Susana Cardoso, Sonia Correia, Renato X Santos, Cristina Carvalho, Maria S Santos, Catarina R Oliveira, George Perry, Mark A Smith, Xiongwei Zhu, Paula I Moreira (Corresponding Author)

Research output: Contribution to journal › Article › peer-review

63 Citations (Scopus)

Abstract

Insulin, long known as an important regulator of blood glucose levels, plays important and multifaceted roles in the brain. It has been reported that insulin is an important neuromodulator, contributing to several neurobiological processes in particular energy homeostasis and cognition. Dysregulation of insulin signaling has been linked to aging and metabolic and neurodegenerative disorders. The first part of this review is devoted to discussion of the critical role of insulin signaling in normal brain function. Then the involvement of impaired insulin signaling in the pathophysiology of diabetes, Alzheimer's, Parkinson's and Huntington's diseases and amyotrophic lateral sclerosis will be discussed. Finally, the potential therapeutic effect of insulin and insulin sensitizers will be examined.

Original language	English
Pages (from-to)	483-507
Number of pages	27
Journal	Journal of Alzheimer's Disease
Volume	18
Issue number	3
DOIs	https://doi.org/10.3233/JAD-2009-1155
Publication status	Published - 30 Oct 2009
Externally published	Yes

Keywords

brain
insulin sensitizers
insulin
insulin signaling
neurodegenerative disorders

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Cite this

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AU - Cardoso, Susana

AU - Correia, Sonia

AU - Santos, Renato X

AU - Carvalho, Cristina

AU - Santos, Maria S

AU - Oliveira, Catarina R

AU - Perry, George

AU - Smith, Mark A

AU - Zhu, Xiongwei

AU - Moreira, Paula I

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N2 - Insulin, long known as an important regulator of blood glucose levels, plays important and multifaceted roles in the brain. It has been reported that insulin is an important neuromodulator, contributing to several neurobiological processes in particular energy homeostasis and cognition. Dysregulation of insulin signaling has been linked to aging and metabolic and neurodegenerative disorders. The first part of this review is devoted to discussion of the critical role of insulin signaling in normal brain function. Then the involvement of impaired insulin signaling in the pathophysiology of diabetes, Alzheimer's, Parkinson's and Huntington's diseases and amyotrophic lateral sclerosis will be discussed. Finally, the potential therapeutic effect of insulin and insulin sensitizers will be examined.

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Insulin is a Two-Edged Knife on the Brain

Abstract

Keywords

UN SDGs

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