Insulin-Like Growth Factor-Binding Proteins of Teleost Fishes

Daniel Garcia de la Serrana* (Corresponding Author), Daniel J. Macqueen

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

65 Citations (Scopus)
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The insulin-like growth factor (Igf) binding protein (Igfbp) family has a broad range of physiological functions and a fascinating evolutionary history. This review focuses on the Igfbps of teleost fishes, where genome duplication events have diversified gene repertoire, function, and physiological regulation-with six core Igfbps expanded into a family of over twenty genes in some lineages. In addition to briefly summarizing the current state of knowledge on teleost Igfbp evolution, function, and expression-level regulation, we highlight gaps in our understanding and promising areas for future work.

Original languageEnglish
Article number80
JournalFrontiers in Endocrinology
Publication statusPublished - 12 Mar 2018

Bibliographical note

Funding: DGS would like to thank the Marine Alliance Science Technology Scotland (MASTS) for their support. MASTS is funded by the Scottish Funding Council (grant reference HR09011) and contributing institutions.


  • Comparative biology
  • Gene family evolution
  • Genome duplication
  • Insulin-like growth factor binding protein
  • Physiology
  • Teleost fish


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