Insulin signaling, glucose metabolism and mitochondria: major players in Alzheimer's disease and diabetes interrelation

Sónia C Correia; Renato X Santos; Cristina Carvalho; Susana Cardoso; Emanuel Candeias; Maria S Santos; Catarina R Oliveira; Paula I Moreira

doi:10.1016/j.brainres.2011.12.063

Insulin signaling, glucose metabolism and mitochondria: major players in Alzheimer's disease and diabetes interrelation

Sónia C Correia, Renato X Santos, Cristina Carvalho, Susana Cardoso, Emanuel Candeias, Maria S Santos, Catarina R Oliveira, Paula I Moreira

University of Coimbra

Research output: Contribution to journal › Review article › peer-review

155 Citations (Scopus)

Abstract

Many epidemiological studies have shown that diabetes, particularly type 2 diabetes, significantly increases the risk to develop Alzheimer's disease. Both diseases share several common abnormalities including impaired glucose metabolism, increased oxidative stress, insulin resistance and deposition of amyloidogenic proteins. It has been suggested that these two diseases disrupt common cellular and molecular pathways and each disease potentiates the progression of the other. This review discusses clinical and biochemical features shared by Alzheimer's disease and diabetes, giving special attention to the involvement of insulin signaling, glucose metabolism and mitochondria. Understanding the key mechanisms underlying this deleterious interaction may provide opportunities for the design of effective therapeutic strategies.

Original language	English
Pages (from-to)	64-78
Number of pages	15
Journal	Brain Research
Volume	1441
Early online date	12 Jan 2012
DOIs	https://doi.org/10.1016/j.brainres.2011.12.063
Publication status	Published - 2 Mar 2012
Externally published	Yes

Bibliographical note

Copyright Â© 2012 Elsevier B.V. All rights reserved.
Acknowledgements This work is supported by the Fundação para a Ciência e a Tecnologia and Fundo Europeu de Desenvolvimento Regional(PTDC/SAU-NEU/103325/2008 and PTDC/SAU-NMC/110990/2009). Sónia C. Correia has a PhD fellowship from the Fundação para a Ciência e a Tecnologia (SFRH/BD/40702/2007).

Keywords

Alzheimer Disease/epidemiology
Animals
Diabetes Mellitus, Type 2/complications
Glucose/metabolism
Humans
Insulin/adverse effects
Mitochondria/physiology
Risk Factors
Signal Transduction/physiology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.brainres.2011.12.063Licence: Unspecified

Cite this

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title = "Insulin signaling, glucose metabolism and mitochondria: major players in Alzheimer's disease and diabetes interrelation",

abstract = "Many epidemiological studies have shown that diabetes, particularly type 2 diabetes, significantly increases the risk to develop Alzheimer's disease. Both diseases share several common abnormalities including impaired glucose metabolism, increased oxidative stress, insulin resistance and deposition of amyloidogenic proteins. It has been suggested that these two diseases disrupt common cellular and molecular pathways and each disease potentiates the progression of the other. This review discusses clinical and biochemical features shared by Alzheimer's disease and diabetes, giving special attention to the involvement of insulin signaling, glucose metabolism and mitochondria. Understanding the key mechanisms underlying this deleterious interaction may provide opportunities for the design of effective therapeutic strategies.",

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note = "Copyright {\^A}{\textcopyright} 2012 Elsevier B.V. All rights reserved. Acknowledgements This work is supported by the Funda{\c c}{\~a}o para a Ci{\^e}ncia e a Tecnologia and Fundo Europeu de Desenvolvimento Regional(PTDC/SAU-NEU/103325/2008 and PTDC/SAU-NMC/110990/2009). S{\'o}nia C. Correia has a PhD fellowship from the Funda{\c c}{\~a}o para a Ci{\^e}ncia e a Tecnologia (SFRH/BD/40702/2007).",

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AU - Correia, Sónia C

AU - Santos, Renato X

AU - Carvalho, Cristina

AU - Cardoso, Susana

AU - Candeias, Emanuel

AU - Santos, Maria S

AU - Oliveira, Catarina R

AU - Moreira, Paula I

N1 - Copyright Â© 2012 Elsevier B.V. All rights reserved. Acknowledgements This work is supported by the Fundação para a Ciência e a Tecnologia and Fundo Europeu de Desenvolvimento Regional(PTDC/SAU-NEU/103325/2008 and PTDC/SAU-NMC/110990/2009). Sónia C. Correia has a PhD fellowship from the Fundação para a Ciência e a Tecnologia (SFRH/BD/40702/2007).

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N2 - Many epidemiological studies have shown that diabetes, particularly type 2 diabetes, significantly increases the risk to develop Alzheimer's disease. Both diseases share several common abnormalities including impaired glucose metabolism, increased oxidative stress, insulin resistance and deposition of amyloidogenic proteins. It has been suggested that these two diseases disrupt common cellular and molecular pathways and each disease potentiates the progression of the other. This review discusses clinical and biochemical features shared by Alzheimer's disease and diabetes, giving special attention to the involvement of insulin signaling, glucose metabolism and mitochondria. Understanding the key mechanisms underlying this deleterious interaction may provide opportunities for the design of effective therapeutic strategies.

AB - Many epidemiological studies have shown that diabetes, particularly type 2 diabetes, significantly increases the risk to develop Alzheimer's disease. Both diseases share several common abnormalities including impaired glucose metabolism, increased oxidative stress, insulin resistance and deposition of amyloidogenic proteins. It has been suggested that these two diseases disrupt common cellular and molecular pathways and each disease potentiates the progression of the other. This review discusses clinical and biochemical features shared by Alzheimer's disease and diabetes, giving special attention to the involvement of insulin signaling, glucose metabolism and mitochondria. Understanding the key mechanisms underlying this deleterious interaction may provide opportunities for the design of effective therapeutic strategies.

KW - Alzheimer Disease/epidemiology

KW - Animals

KW - Diabetes Mellitus, Type 2/complications

KW - Glucose/metabolism

KW - Humans

KW - Insulin/adverse effects

KW - Mitochondria/physiology

KW - Risk Factors

KW - Signal Transduction/physiology

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DO - 10.1016/j.brainres.2011.12.063

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EP - 78

JO - Brain Research

JF - Brain Research

ER -

Insulin signaling, glucose metabolism and mitochondria: major players in Alzheimer's disease and diabetes interrelation

Abstract

Bibliographical note

Keywords

UN SDGs

Access to Document

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Cite this