Intensive immunosuppression treatment for central retinal vein occlusion in a young adult: a case report

F. Willermain, Kathrin Greiner, John Vincent Forrester

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3 Citations (Scopus)


Purpose: To describe a case of severe central retinal vein occlusion (CRVO) in a young patient, in whom intensive immunosuppressive therapy improved the clinical outcome. Case report: A 35-year-old men presented with a first episode of CRVO in his right eye in 1990. Despite corticosteroids, and laser treatment, rubeotic glaucoma developed and the eye had to be enucleated. Seven years later, CRVO developed in the fellow eye, with venous tortuosity and haemorrhages. An extensive systemic workup was unremarkable. Corticosteroids failed to control the clinical situation. Cells were seen in the anterior vitreous. Visual acuity decreased to 2/60. Cyclosporine and azathioprine were added, but did not prevent recurrences. Campath-1H treatment was then started and visual acuity improved to 6/36. In November 2000, visual acuity was 6/24 and haemorrhages had cleared. Discussion: Many authors have proposed a role for inflammation in the pathophysiology of CRVO in young patients. However, there is no general agreement on corticosteroid use in these patients. Our case illustrates that, in some settings, high-dose corticosteroids and intensive immunosuppression might be used successfully to preserve vision.

Original languageEnglish
Pages (from-to)141-145
Number of pages4
JournalOcular Immunology and Inflammation
Issue number2
Publication statusPublished - 2002


  • CRVO
  • young adults
  • vasculitis
  • immunosuppression


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