Abstract
Sprint intensity interval training (SIT) is reported to improve blood glucose control and may be a useful public health tool. The sirtuins and associated genes are emerging as key players in blood glucose control. This study investigated the interplay between the sirtuin/NAD system and individual variation in insulin sensitivity responses after SIT in young healthy individuals. Before and after 4 weeks of SIT body mass and fat percentage were measured and oral glucose tolerance tests (OGTT) performed in 20 young healthy participants (7 females). Blood gene expression profiles (all 7 mammalian sirtuin genes and 15 enzymes
involved in conversion of tryptophan, bioavailable vitamin B3 and metabolic precursors to NAD). NAD/NADP was measured in whole blood. Significant reductions in body weight and body fat post-SIT were associated with altered lipid profiles, NAD/NADP and regulation of components of the sirtuin/NAD system (NAMPT, NMNAT1, CD38 and ABCA1). Variable improvements in measured metabolic health parameters were evident and attributed to different responses in males and females, together with marked inter-individual variation in responses of the sirtuin/NAD system to SIT.
involved in conversion of tryptophan, bioavailable vitamin B3 and metabolic precursors to NAD). NAD/NADP was measured in whole blood. Significant reductions in body weight and body fat post-SIT were associated with altered lipid profiles, NAD/NADP and regulation of components of the sirtuin/NAD system (NAMPT, NMNAT1, CD38 and ABCA1). Variable improvements in measured metabolic health parameters were evident and attributed to different responses in males and females, together with marked inter-individual variation in responses of the sirtuin/NAD system to SIT.
Original language | English |
---|---|
Pages (from-to) | 84-93 |
Number of pages | 10 |
Journal | Applied Physiology Nutrition and Metabolism / Physiologie Appliquée, Nutrition et Métabolisme |
Volume | 43 |
Issue number | 1 |
Early online date | 13 Sept 2017 |
DOIs | |
Publication status | Published - Jan 2018 |
Bibliographical note
AcknowledgementsWe thank the Human Nutrition and Genomics Units, Rowett Institute, University of Aberdeen for technical support. This work was supported by the Scottish Government's Rural and Environment Science and Analytical Services Division and an NHS Grampian Endowment Fund grant.
Keywords
- insulin sensitivity
- interval exercise
- body composition
- sirtuin system
- inter-individual variation
- GeXP