The surveillance and elimination of fungal pathogens rely heavily on the sentinel behaviour of phagocytic cells of the innate immune system, especially macrophages and neutrophils. The efficiency by which these cells recognize, uptake and kill fungal pathogens depends on the size, shape and composition of the fungal cells and the success or failure of various fungal mechanisms of immune evasion. In this Review, we describe how fungi, particularly Candida albicans, interact with phagocytic cells and discuss the many factors that contribute to fungal immune evasion and prevent host elimination of these pathogenic microorganisms.
Bibliographical noteThe authors acknowledge L. Wight and the microscopy facility at the University of Aberdeen. The authors also acknowledge the support of the Wellcome Trust (grants 080088. 075470 and 099215) and a Wellcome Trust Strategic Award for Medical Mycology and Fungal Immunology (grant 097377).
- Fungal host response
- Fungal immune evasion
- Fungal infection
- Fungal pathogenesis