Interactions of fungal pathogens with phagocytes

Lars P Erwig; Neil A R Gow

doi:10.1038/nrmicro.2015.21

Interactions of fungal pathogens with phagocytes

Lars P Erwig, Neil A R Gow

Medical Sciences

Research output: Contribution to journal › Literature review

443 Citations (Scopus)

Abstract

The surveillance and elimination of fungal pathogens rely heavily on the sentinel behaviour of phagocytic cells of the innate immune system, especially macrophages and neutrophils. The efficiency by which these cells recognize, uptake and kill fungal pathogens depends on the size, shape and composition of the fungal cells and the success or failure of various fungal mechanisms of immune evasion. In this Review, we describe how fungi, particularly Candida albicans, interact with phagocytic cells and discuss the many factors that contribute to fungal immune evasion and prevent host elimination of these pathogenic microorganisms.

Original language	English
Pages (from-to)	163-176
Number of pages	14
Journal	Nature Reviews Microbiology
Volume	14
Issue number	3
Early online date	8 Feb 2016
DOIs	https://doi.org/10.1038/nrmicro.2015.21
Publication status	Published - Mar 2016

Bibliographical note

The authors acknowledge L. Wight and the microscopy facility at the University of Aberdeen. The authors also acknowledge the support of the Wellcome Trust (grants 080088. 075470 and 099215) and a Wellcome Trust Strategic Award for Medical Mycology and Fungal Immunology (grant 097377).

Keywords

Fungal host response
Fungal immune evasion
Fungal infection
Fungal pathogenesis

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10.1038/nrmicro.2015.21Licence: Unspecified

Microscopy and Histology
Debbie Wilkinson (Manager) & Gillian Milne (Manager)
Medical Sciences
Research Facilities: Facility

Cite this

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title = "Interactions of fungal pathogens with phagocytes",

abstract = "The surveillance and elimination of fungal pathogens rely heavily on the sentinel behaviour of phagocytic cells of the innate immune system, especially macrophages and neutrophils. The efficiency by which these cells recognize, uptake and kill fungal pathogens depends on the size, shape and composition of the fungal cells and the success or failure of various fungal mechanisms of immune evasion. In this Review, we describe how fungi, particularly Candida albicans, interact with phagocytic cells and discuss the many factors that contribute to fungal immune evasion and prevent host elimination of these pathogenic microorganisms.",

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AB - The surveillance and elimination of fungal pathogens rely heavily on the sentinel behaviour of phagocytic cells of the innate immune system, especially macrophages and neutrophils. The efficiency by which these cells recognize, uptake and kill fungal pathogens depends on the size, shape and composition of the fungal cells and the success or failure of various fungal mechanisms of immune evasion. In this Review, we describe how fungi, particularly Candida albicans, interact with phagocytic cells and discuss the many factors that contribute to fungal immune evasion and prevent host elimination of these pathogenic microorganisms.

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KW - Fungal immune evasion

KW - Fungal infection

KW - Fungal pathogenesis

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M3 - Literature review

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ER -

Interactions of fungal pathogens with phagocytes

Abstract

Bibliographical note

Keywords

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Microscopy and Histology

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