Abstract
Background: Older people represent the majority of cancer patients but their specific needs are often ignored in the development of health-related quality of life (HRQOL) instruments. The European Organisation for Research and Treatment of Cancer (EORTC) QLQ-ELD15 was developed to supplement the EORTC’s core questionnaire, the QLQ-C30, for measuring HRQOL in patients aged >70 years in oncology studies.
Methods: Patients (n=518) from 10 countries completed the QLQ-C30, QLQ-ELD15 and a debriefing interview. Eighty two clinically stable patients repeated the questionnaires 1 week later (test–retest analysis) and 107 others, with an expected change in clinical status, repeated the questionnaires 3 months later (response to change analysis, RCA).
Results: Information from the debriefing interview, factor analysis and item response theory analysis resulted in the removal of one item (QLQ-ELD15QLQ-ELD14) and revision of the proposed scale structure to five scales (mobility, worries about others, future worries, maintaining purpose and illness burden) and two single items (joint stiffness and family support). Convergent validity was good. In known-group comparisons, the QLQ-ELD14 differentiated between patients with different disease stage, treatment intention, number of comorbidities, performance status and geriatric screening scores. Test–retest and RCA analyses were equivocal.
Conclusion: The QLQ-ELD14 is a validated HRQOL questionnaire for cancer patients aged 70 years. Changes in elderly patients’ self-reported HRQOL may be related to both cancer evolution and non-clinical events.
Methods: Patients (n=518) from 10 countries completed the QLQ-C30, QLQ-ELD15 and a debriefing interview. Eighty two clinically stable patients repeated the questionnaires 1 week later (test–retest analysis) and 107 others, with an expected change in clinical status, repeated the questionnaires 3 months later (response to change analysis, RCA).
Results: Information from the debriefing interview, factor analysis and item response theory analysis resulted in the removal of one item (QLQ-ELD15QLQ-ELD14) and revision of the proposed scale structure to five scales (mobility, worries about others, future worries, maintaining purpose and illness burden) and two single items (joint stiffness and family support). Convergent validity was good. In known-group comparisons, the QLQ-ELD14 differentiated between patients with different disease stage, treatment intention, number of comorbidities, performance status and geriatric screening scores. Test–retest and RCA analyses were equivocal.
Conclusion: The QLQ-ELD14 is a validated HRQOL questionnaire for cancer patients aged 70 years. Changes in elderly patients’ self-reported HRQOL may be related to both cancer evolution and non-clinical events.
Original language | English |
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Pages (from-to) | 852-858 |
Number of pages | 7 |
Journal | British Journal of Cancer |
Volume | 109 |
Early online date | 18 Jul 2013 |
DOIs | |
Publication status | Published - 20 Aug 2013 |
Bibliographical note
ACKNOWLEDGEMENTSThis study was funded by the European Organisation for Research and Treatment of Cancer Quality of Life (EORTC QOL) Group who approved the manuscript before submission. We would like to thank the reviewers from the EORTC QOL group, Mogens Grønvold, Galina Velikova, Susanne Singer, Bernhard Holzner,
Eva Greimel, Jaap Reijneveld and Andrew Bottomley. The following all contributed to participant recruitment, for which we are grateful: Dr Valerie Quipourt, Dr Genevie`ve Imbert, Dr Bernhard Holzner, Dr Annemie Courtens, Dr Jessie Wu, Ms Anne Jacob, Ms Janet Prouse, Mrs Christine Brannan and Mrs Melanie Winterbotham. We acknowledge all the centres, investigators and patients who took time to participate in the study.
Keywords
- health-related quality of life
- elderly
- European Organisation for Research and Treatment of Cancer QLQ-C30
- module validation study