Interrelationships between body mass index, total IgE, and blood eosinophils count in healthy subjects

R Amaral, T Jacinto, A Malinovschi, C Janson, D Price, J Fonseca, K Alving

Research output: Contribution to journalAbstractpeer-review


Aim: To assess the influence of total IgE on the association between body mass index (BMI), smoking status and blood eosinophil (B-Eos) count in healthy subjects from a large population-based sample.Methods: We analysed data on 4,785 children/adolescents (<18 years) and 5,563 adults (18-79 years) from the 2005-2006 US National Health and Nutrition Examination Survey. Subjects without any reported respiratory disease, hay fever and/or non-respiratory diseases significantly associated with B-Eos count (heart diseases, stroke, and metabolic syndrome; Amaral, R. et al. Clin Transl Allergy 2021;11:e12036), were considered healthy. Two multivariate regression models were developed with B-Eos count as outcome variable: model 1 included age, sex, race/ethnicity, BMI categories, and smoking status (in adults only); and model 2 also included total IgE.Results: A total of 3,541 healthy children/adolescents and 1,465 adults were included. In model 1, B-Eos count was significantly associated with overweight/obesity in children/adolescents and adults (p=0.041 and p=0.039, respectively) as well as with current smoking (p=0.041). In model 2, B-Eos count was significantly associated with total IgE in both age groups (p<0.001), and current smoking remained significant (p=0.020). However, BMI was no longer associated with B-Eos count (p>0.05 both groups).Conclusion: This study showed an independent relationship between B-Eos count and total IgE in healthy subjects. When adjusted for total IgE, the association between B-Eos count and BMI disappeared whereas the association with current smoking remained, indicating possible different mechanisms underlying increased B-Eos count upon these exposures.FootnotesCite this article as Eur Respir J 2022; 60: Suppl. 66, 412.This article was presented at the 2022 ERS International Congress, in session “-”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at (ERS member access only).
Original languageEnglish
Article number412
JournalEuropean Respiratory Journal
Issue numberSuppl. 66
Early online date1 Dec 2022
Publication statusPublished - 2022
EventEuropean Respiratory Society (ERS) International Congress. - FIRA Barcelona Gran Via Congress Centre, Barcelona, Spain
Duration: 4 Sept 20226 Sept 2022

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