Intravenous sodium nitrite in acute ST-elevation myocardial infarction: a randomized controlled trial (NIAMI)

Nishat Siddiqi; Christopher Neil; Margaret Bruce; Graeme Maclennan; Seonaidh Claire Cotton; Sofia Papadopoulou; Martin Feelisch; Nicholas Bunce; Pitt O Lim; David Hildick-Smith; John Horowitz; Melanie Madhani; Nicholas Boon; Dana Dawson; Juan Carlos Kaski; Michael Frenneaux; NIAMI investigators

doi:10.1093/eurheartj/ehu096

Intravenous sodium nitrite in acute ST-elevation myocardial infarction: a randomized controlled trial (NIAMI)

Nishat Siddiqi, Christopher Neil, Margaret Bruce, Graeme Maclennan, Seonaidh Claire Cotton, Sofia Papadopoulou, Martin Feelisch, Nicholas Bunce, Pitt O Lim, David Hildick-Smith, John Horowitz, Melanie Madhani, Nicholas Boon, Dana Dawson, Juan Carlos Kaski, Michael Frenneaux, NIAMI investigators

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Abstract

Despite prompt revascularization of acute myocardial infarction (AMI), substantial myocardial injury may occur, in part a consequence of ischaemia reperfusion injury (IRI). There has been considerable interest in therapies that may reduce IRI. In experimental models of AMI, sodium nitrite substantially reduces IRI. In this doubleblind randomized placebo controlled parallel-group trial, we investigated the effects of sodium nitrite administered immediately prior to reperfusion in patients with acute ST-elevation myocardial infarction (STEMI).

Original language	English
Pages (from-to)	1255-1262
Number of pages	8
Journal	European Heart Journal
Volume	35
Issue number	19
Early online date	17 Mar 2014
DOIs	https://doi.org/10.1093/eurheartj/ehu096
Publication status	Published - May 2014

Bibliographical note

Funding
This study was funded by the UK Medical Research Council. Funding to pay the Open Access publication charges for this article was provided by the University of Aberdeen.

Acknowledgements
We would like to thank our patients and the staff of the cardiology and radiology/cardiac MRI departments at all sites. We are grateful for the support of the staff at the Centre for Healthcare Randomised Trials at the University of Aberdeen

Keywords

acute myocardial infarction
ischaemia-reperfusion injury
cardioprotection
nitrite

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10.1093/eurheartj/ehu096Licence: CC BY-NC

Siddiqi 2014
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License(http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Seonaidh Cotton
- School of Medicine, Medical Sciences & Nutrition, Health Services Research Unit (HSRU) - Senior Trial Manager
- School of Medicine, Medical Sciences & Nutrition, Centre for Healthcare Randomised Trials (CHaRT)
Person: Academic Related - Management
Dana Dawson
- School of Medicine, Medical Sciences & Nutrition, Cardiometabolic Disease
- School of Medicine, Medical Sciences & Nutrition, Applied Medicine - Chair in Cardiovascular Medicine
- Institute of Medical Sciences
Person: Clinical Academic
Graeme MacLennan
Person: Academic, Academic Related - Research

Cite this

Siddiqi, N., Neil, C., Bruce, M., Maclennan, G., Cotton, S. C., Papadopoulou, S., Feelisch, M., Bunce, N., Lim, P. O., Hildick-Smith, D., Horowitz, J., Madhani, M., Boon, N., Dawson, D., Kaski, J. C., Frenneaux, M., & NIAMI investigators (2014). Intravenous sodium nitrite in acute ST-elevation myocardial infarction: a randomized controlled trial (NIAMI). European Heart Journal, 35(19), 1255-1262. https://doi.org/10.1093/eurheartj/ehu096

Siddiqi, N, Neil, C, Bruce, M, Maclennan, G , Cotton, SC, Papadopoulou, S, Feelisch, M, Bunce, N, Lim, PO, Hildick-Smith, D, Horowitz, J, Madhani, M, Boon, N, Dawson, D, Kaski, JC, Frenneaux, M & NIAMI investigators 2014, 'Intravenous sodium nitrite in acute ST-elevation myocardial infarction: a randomized controlled trial (NIAMI)', European Heart Journal, vol. 35, no. 19, pp. 1255-1262. https://doi.org/10.1093/eurheartj/ehu096

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abstract = "Despite prompt revascularization of acute myocardial infarction (AMI), substantial myocardial injury may occur, in part a consequence of ischaemia reperfusion injury (IRI). There has been considerable interest in therapies that may reduce IRI. In experimental models of AMI, sodium nitrite substantially reduces IRI. In this doubleblind randomized placebo controlled parallel-group trial, we investigated the effects of sodium nitrite administered immediately prior to reperfusion in patients with acute ST-elevation myocardial infarction (STEMI).",

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AU - Feelisch, Martin

AU - Bunce, Nicholas

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AU - Frenneaux, Michael

AU - NIAMI investigators

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N2 - Despite prompt revascularization of acute myocardial infarction (AMI), substantial myocardial injury may occur, in part a consequence of ischaemia reperfusion injury (IRI). There has been considerable interest in therapies that may reduce IRI. In experimental models of AMI, sodium nitrite substantially reduces IRI. In this doubleblind randomized placebo controlled parallel-group trial, we investigated the effects of sodium nitrite administered immediately prior to reperfusion in patients with acute ST-elevation myocardial infarction (STEMI).

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KW - acute myocardial infarction

KW - ischaemia-reperfusion injury

KW - cardioprotection

KW - nitrite

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ER -

Intravenous sodium nitrite in acute ST-elevation myocardial infarction: a randomized controlled trial (NIAMI)

Abstract

Bibliographical note

Keywords

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Profiles

Seonaidh Cotton

Dana Dawson

Graeme MacLennan

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