Intravenous sodium nitrite in acute ST-elevation myocardial infarction: a randomized controlled trial (NIAMI)

Nishat Siddiqi, Christopher Neil, Margaret Bruce, Graeme Maclennan, Seonaidh Claire Cotton, Sofia Papadopoulou, Martin Feelisch, Nicholas Bunce, Pitt O Lim, David Hildick-Smith, John Horowitz, Melanie Madhani, Nicholas Boon, Dana Dawson, Juan Carlos Kaski, Michael Frenneaux, NIAMI investigators

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114 Citations (Scopus)
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Despite prompt revascularization of acute myocardial infarction (AMI), substantial myocardial injury may occur, in part a consequence of ischaemia reperfusion injury (IRI). There has been considerable interest in therapies that may reduce IRI. In experimental models of AMI, sodium nitrite substantially reduces IRI. In this doubleblind randomized placebo controlled parallel-group trial, we investigated the effects of sodium nitrite administered immediately prior to reperfusion in patients with acute ST-elevation myocardial infarction (STEMI).
Original languageEnglish
Pages (from-to)1255-1262
Number of pages8
JournalEuropean Heart Journal
Issue number19
Early online date17 Mar 2014
Publication statusPublished - May 2014

Bibliographical note

This study was funded by the UK Medical Research Council. Funding to pay the Open Access publication charges for this article was provided by the University of Aberdeen.

We would like to thank our patients and the staff of the cardiology and radiology/cardiac MRI departments at all sites. We are grateful for the support of the staff at the Centre for Healthcare Randomised Trials at the University of Aberdeen


  • acute myocardial infarction
  • ischaemia-reperfusion injury
  • cardioprotection
  • nitrite


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