Investigating retinal therapies using ex vivo retinal explants

Virpi Alarautalahti; Symantas Ragauskas; Andrea Holme; Hannele Uusitalo-Järvinen; Hannu Uusitalo; Jari Hyttinen; Giedrius Kalesnykas; Soile Nymark

doi:10.3389/conf.fnins.2016.93.00036

Investigating retinal therapies using ex vivo retinal explants

Virpi Alarautalahti^*, Symantas Ragauskas, Andrea Holme, Hannele Uusitalo-Järvinen, Hannu Uusitalo, Jari Hyttinen, Giedrius Kalesnykas, Soile Nymark

^*Corresponding author for this work

Research output: Contribution to conference › Abstract › peer-review

Abstract

Retinal degenerative diseases cause an enormous economic burden to the society and decrease the life quality and independence of affected patients. Currently, there are no therapies that would cure these diseases and restore vision. Thus, new treatments are urgently needed. In vitro retina model systems would facilitate the therapy development, and enable the investigation of the effects, benefits and risks of the medical treatments to the retinal tissue. In this study, we tested an organotypic retinal explant culture system and its potential as a tool for the investigations of retinal therapies, focusing on the effects of drugs to the functioning and morphology of the retina.

Original language	English
DOIs	https://doi.org/10.3389/conf.fnins.2016.93.00036
Publication status	Published - 24 Jun 2016
Externally published	Yes
Event	MEA Meeting 2016, 10th International Meeting on Substrate-Integrated Electrode Arrays - Reutlingen, Germany Duration: 28 Jun 2016 → 1 Jul 2016

Conference

Conference	MEA Meeting 2016, 10th International Meeting on Substrate-Integrated Electrode Arrays
Country/Territory	Germany
City	Reutlingen
Period	28/06/16 → 1/07/16

Bibliographical note

Acknowledgements
This work was supported by the Academy of Finland (grants 260375, 287287 and 294054), by iBioMEP graduate school and by TEKES.

Keywords

Retina
Culture system
Retinal explants
perforated MEA

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https://www.frontiersin.org/10.3389/conf.fnins.2016.93.00036/event_abstract

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abstract = "Retinal degenerative diseases cause an enormous economic burden to the society and decrease the life quality and independence of affected patients. Currently, there are no therapies that would cure these diseases and restore vision. Thus, new treatments are urgently needed. In vitro retina model systems would facilitate the therapy development, and enable the investigation of the effects, benefits and risks of the medical treatments to the retinal tissue. In this study, we tested an organotypic retinal explant culture system and its potential as a tool for the investigations of retinal therapies, focusing on the effects of drugs to the functioning and morphology of the retina.",

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note = "Acknowledgements This work was supported by the Academy of Finland (grants 260375, 287287 and 294054), by iBioMEP graduate school and by TEKES.; MEA Meeting 2016, 10th International Meeting on Substrate-Integrated Electrode Arrays ; Conference date: 28-06-2016 Through 01-07-2016",

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T1 - Investigating retinal therapies using ex vivo retinal explants

AU - Alarautalahti, Virpi

AU - Ragauskas, Symantas

AU - Holme, Andrea

AU - Uusitalo-Järvinen, Hannele

AU - Uusitalo, Hannu

AU - Hyttinen, Jari

AU - Kalesnykas, Giedrius

AU - Nymark, Soile

N1 - Acknowledgements This work was supported by the Academy of Finland (grants 260375, 287287 and 294054), by iBioMEP graduate school and by TEKES.

PY - 2016/6/24

Y1 - 2016/6/24

N2 - Retinal degenerative diseases cause an enormous economic burden to the society and decrease the life quality and independence of affected patients. Currently, there are no therapies that would cure these diseases and restore vision. Thus, new treatments are urgently needed. In vitro retina model systems would facilitate the therapy development, and enable the investigation of the effects, benefits and risks of the medical treatments to the retinal tissue. In this study, we tested an organotypic retinal explant culture system and its potential as a tool for the investigations of retinal therapies, focusing on the effects of drugs to the functioning and morphology of the retina.

AB - Retinal degenerative diseases cause an enormous economic burden to the society and decrease the life quality and independence of affected patients. Currently, there are no therapies that would cure these diseases and restore vision. Thus, new treatments are urgently needed. In vitro retina model systems would facilitate the therapy development, and enable the investigation of the effects, benefits and risks of the medical treatments to the retinal tissue. In this study, we tested an organotypic retinal explant culture system and its potential as a tool for the investigations of retinal therapies, focusing on the effects of drugs to the functioning and morphology of the retina.

KW - Retina

KW - Culture system

KW - Retinal explants

KW - perforated MEA

U2 - 10.3389/conf.fnins.2016.93.00036

DO - 10.3389/conf.fnins.2016.93.00036

M3 - Abstract

T2 - MEA Meeting 2016, 10th International Meeting on Substrate-Integrated Electrode Arrays

Y2 - 28 June 2016 through 1 July 2016

ER -

Investigating retinal therapies using ex vivo retinal explants

Abstract

Conference

Bibliographical note

Keywords

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