Retinal degenerative diseases cause an enormous economic burden to the society and decrease the life quality and independence of affected patients. Currently, there are no therapies that would cure these diseases and restore vision. Thus, new treatments are urgently needed. In vitro retina model systems would facilitate the therapy development, and enable the investigation of the effects, benefits and risks of the medical treatments to the retinal tissue. In this study, we tested an organotypic retinal explant culture system and its potential as a tool for the investigations of retinal therapies, focusing on the effects of drugs to the functioning and morphology of the retina.
|Publication status||Published - 24 Jun 2016|
|Event||MEA Meeting 2016, 10th International Meeting on Substrate-Integrated Electrode Arrays - Reutlingen, Germany|
Duration: 28 Jun 2016 → 1 Jul 2016
|Conference||MEA Meeting 2016, 10th International Meeting on Substrate-Integrated Electrode Arrays|
|Period||28/06/16 → 1/07/16|
This work was supported by the Academy of Finland (grants 260375, 287287 and 294054), by iBioMEP graduate school and by TEKES.
- Culture system
- Retinal explants
- perforated MEA