Investigating the Effect of Redox Agents on Structural Re-Arrangement of the BK Channel RCK1-RCK2 Linker using Fluorescence Lifetime Imaging Microscopy

Iain Rowe; Edward Rowan; Rory Duncan; Mike Shipston

doi:10.1016/j.bpj.2011.11.3745

Investigating the Effect of Redox Agents on Structural Re-Arrangement of the BK Channel RCK1-RCK2 Linker using Fluorescence Lifetime Imaging Microscopy

Iain Rowe, Edward Rowan, Rory Duncan, Mike Shipston

Medical Education

Research output: Contribution to journal › Article › peer-review

Abstract

Alternative splicing generates considerable functional diversity of large conductance calcium- and voltage-activated potassium (BK) channels. For example, inclusion of the STREX (STRess-activated EXon) insert into the unstructured cytosolic linker between the two RCK domains of the channel generates a cysteine rich domain (CRD) that confers intrinsic hypoxia sensitivity to the channel ...

Original language	English
Pages (from-to)	689a-690a
Journal	Biophysical Journal
Volume	102
Issue number	3, Supplement 1
DOIs	https://doi.org/10.1016/j.bpj.2011.11.3745
Publication status	Published - Jan 2012

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10.1016/j.bpj.2011.11.3745

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title = "Investigating the Effect of Redox Agents on Structural Re-Arrangement of the BK Channel RCK1-RCK2 Linker using Fluorescence Lifetime Imaging Microscopy",

abstract = "Alternative splicing generates considerable functional diversity of large conductance calcium- and voltage-activated potassium (BK) channels. For example, inclusion of the STREX (STRess-activated EXon) insert into the unstructured cytosolic linker between the two RCK domains of the channel generates a cysteine rich domain (CRD) that confers intrinsic hypoxia sensitivity to the channel ...",

author = "Iain Rowe and Edward Rowan and Rory Duncan and Mike Shipston",

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AU - Duncan, Rory

AU - Shipston, Mike

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AB - Alternative splicing generates considerable functional diversity of large conductance calcium- and voltage-activated potassium (BK) channels. For example, inclusion of the STREX (STRess-activated EXon) insert into the unstructured cytosolic linker between the two RCK domains of the channel generates a cysteine rich domain (CRD) that confers intrinsic hypoxia sensitivity to the channel ...

U2 - 10.1016/j.bpj.2011.11.3745

DO - 10.1016/j.bpj.2011.11.3745

M3 - Article

SN - 0006-3495

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SP - 689a-690a

JO - Biophysical Journal

JF - Biophysical Journal

IS - 3, Supplement 1

ER -

Investigating the Effect of Redox Agents on Structural Re-Arrangement of the BK Channel RCK1-RCK2 Linker using Fluorescence Lifetime Imaging Microscopy

Abstract

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