TY - JOUR
T1 - Investigating the inflammatory status in the patients candidate for second angiography after coronary stent implantation
AU - Soflaei, Sara Saffar
AU - Saberi-Karimian, Maryam
AU - Baktashian, Mojtaba
AU - Tajfard, Mohammad
AU - Alimi, Hedieh
AU - Tayefi, Maryam
AU - Moohebati, Mohsen
AU - Ebrahimi, Mahmoud
AU - Kosari, Negin
AU - Dehghani, Mashallah
AU - Esmaily, Habibollah
AU - Hashemi, Seyed Mohammad
AU - Ferns, Gordon A.
AU - Salehi, Mansoor
AU - Pasdar, Alireza
AU - Ghayour-Mobarhan, Majid
N1 - Funding Information:
This study was supported by Mashhad and Isfahan University of Medical Sciences [ID: 930834]. The authors thank technicians of Sina, Sadi, Ghaem catheterisation laboratory and technicians of Isfahan Alzahra genetics laboratory.
PY - 2023
Y1 - 2023
N2 - Background: Inflammation has been shown to be an important feature of atherosclerosis. We aimed to assess a profile of inflammatory cytokines and growth factors in patients with established coronary artery disease (CAD), 12 months after stent implantation. Methods: A total of 193 patients with CAD, who were candidates for angiography, 12 months after stent implantation (cases), were compared with 107 patients with CAD, who were candidates for their first angiography (controls). Fasting blood glucose (FBG), triglycerides (TGs), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and high-sensitive C-reactive protein (hs-CRP) were measured using routine methods. The serum concentrations of IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, TNF-α, IFN-γ, MCP-1, EGF and VEGF were determined using competitive chemiluminescence immunoassays. Results: Serum levels of FBG (p =.002), TG (p =.029) and hs-CRP (p =.005) were significantly lower in cases than controls. The cytokines and growth factor profiles in cases were significantly different from controls. After multivariate analysis, serum levels of IL-2 (p <.001), IL-4 (p =.028) were significantly lower in cases compared with the controls while serum levels of IL-8, TNF-α, MCP-1, EGF and VEGF were significantly higher in the cases (p <.001). Conclusions: In patients with CAD and higher consumption of drug used (statins, aspirin and glucose lowering agents) to mitigate the risk of a secondary event, the level of hs-CRP one year after stent implantation decreased despite of significant higher serum levels of pro- and anti-inflammatory cytokines and growth factors.
AB - Background: Inflammation has been shown to be an important feature of atherosclerosis. We aimed to assess a profile of inflammatory cytokines and growth factors in patients with established coronary artery disease (CAD), 12 months after stent implantation. Methods: A total of 193 patients with CAD, who were candidates for angiography, 12 months after stent implantation (cases), were compared with 107 patients with CAD, who were candidates for their first angiography (controls). Fasting blood glucose (FBG), triglycerides (TGs), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and high-sensitive C-reactive protein (hs-CRP) were measured using routine methods. The serum concentrations of IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, TNF-α, IFN-γ, MCP-1, EGF and VEGF were determined using competitive chemiluminescence immunoassays. Results: Serum levels of FBG (p =.002), TG (p =.029) and hs-CRP (p =.005) were significantly lower in cases than controls. The cytokines and growth factor profiles in cases were significantly different from controls. After multivariate analysis, serum levels of IL-2 (p <.001), IL-4 (p =.028) were significantly lower in cases compared with the controls while serum levels of IL-8, TNF-α, MCP-1, EGF and VEGF were significantly higher in the cases (p <.001). Conclusions: In patients with CAD and higher consumption of drug used (statins, aspirin and glucose lowering agents) to mitigate the risk of a secondary event, the level of hs-CRP one year after stent implantation decreased despite of significant higher serum levels of pro- and anti-inflammatory cytokines and growth factors.
KW - anti-inflammatory cytokines
KW - Coronary artery disease
KW - growth factors
KW - pro-inflammatory cytokines
UR - http://www.scopus.com/inward/record.url?scp=85135787340&partnerID=8YFLogxK
U2 - 10.1080/00015385.2022.2040821
DO - 10.1080/00015385.2022.2040821
M3 - Article
C2 - 35946611
AN - SCOPUS:85135787340
SN - 0001-5385
VL - 78
SP - 80
EP - 85
JO - Acta Cardiologica
JF - Acta Cardiologica
IS - 1
ER -