Ion Channels As Emerging Metabolic Regulators and Therapeutic Targets in Osteoarthritis: Nav1.7 As a Recent Exemplar

Ali Mobasheri; Csaba Matta; Wayne Giles; Ann M. Rajnicek; Stefan Ivanavicius

doi:10.1089/bioe.2024.0013

Ion Channels As Emerging Metabolic Regulators and Therapeutic Targets in Osteoarthritis: Nav1.7 As a Recent Exemplar

Ali Mobasheri^*, Csaba Matta, Wayne Giles, Ann M. Rajnicek, Stefan Ivanavicius

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

8 Downloads (Pure)

Abstract

A recent article has revealed the potential of a subtype of voltage-gated sodium channel as a metabolic regulator and therapeutic target in osteoarthritis (OA). Functional Na_v1.7 expression was identified in human OA-associated chondrocytes and shown in several genetic mouse models to promote disease progression. Thus, targeting and modulating it, including pharmacologically, could represent a previously unexplored avenue for developing therapeutic interventions to manage the disease. This study further highlights the need to understand the chondrocyte “channelome” more completely to unravel the diverse roles of ion channels in cartilage homeostasis and their clinical potential.

Original language	English
Pages (from-to)	54-56
Number of pages	3
Journal	Bioelectricity
Volume	6
Issue number	1
Early online date	15 Mar 2024
DOIs	https://doi.org/10.1089/bioe.2024.0013
Publication status	Published - Mar 2024

Keywords

chondrocyte
ion channel
metabolic regulation
Na1.7
osteoarthritis
therapeutic target

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1089/bioe.2024.0013Licence: Unspecified

Mobasheri_etal_B_Ion_Channels_As_AAM
This manuscript has been made open access under a Creative Commons Attribution (CC BY) licence under the terms of the University of Aberdeen Research Publications Policy. https://creativecommons.org/licenses/by/4.0/
Accepted author manuscript, 238 KBLicence: CC BY

Cite this

@article{a3e716a99a9e4e20b702ea5ddc114ddb,

title = "Ion Channels As Emerging Metabolic Regulators and Therapeutic Targets in Osteoarthritis: Nav1.7 As a Recent Exemplar",

abstract = "A recent article has revealed the potential of a subtype of voltage-gated sodium channel as a metabolic regulator and therapeutic target in osteoarthritis (OA). Functional Nav1.7 expression was identified in human OA-associated chondrocytes and shown in several genetic mouse models to promote disease progression. Thus, targeting and modulating it, including pharmacologically, could represent a previously unexplored avenue for developing therapeutic interventions to manage the disease. This study further highlights the need to understand the chondrocyte “channelome” more completely to unravel the diverse roles of ion channels in cartilage homeostasis and their clinical potential.",

keywords = "chondrocyte, ion channel, metabolic regulation, Na1.7, osteoarthritis, therapeutic target",

author = "Ali Mobasheri and Csaba Matta and Wayne Giles and Rajnicek, {Ann M.} and Stefan Ivanavicius",

year = "2024",

month = mar,

doi = "10.1089/bioe.2024.0013",

language = "English",

volume = "6",

pages = "54--56",

journal = "Bioelectricity",

issn = "2576-3105",

publisher = "Mary Ann Liebert Inc.",

number = "1",

}

TY - JOUR

T1 - Ion Channels As Emerging Metabolic Regulators and Therapeutic Targets in Osteoarthritis

T2 - Nav1.7 As a Recent Exemplar

AU - Mobasheri, Ali

AU - Matta, Csaba

AU - Giles, Wayne

AU - Rajnicek, Ann M.

AU - Ivanavicius, Stefan

PY - 2024/3

Y1 - 2024/3

N2 - A recent article has revealed the potential of a subtype of voltage-gated sodium channel as a metabolic regulator and therapeutic target in osteoarthritis (OA). Functional Nav1.7 expression was identified in human OA-associated chondrocytes and shown in several genetic mouse models to promote disease progression. Thus, targeting and modulating it, including pharmacologically, could represent a previously unexplored avenue for developing therapeutic interventions to manage the disease. This study further highlights the need to understand the chondrocyte “channelome” more completely to unravel the diverse roles of ion channels in cartilage homeostasis and their clinical potential.

AB - A recent article has revealed the potential of a subtype of voltage-gated sodium channel as a metabolic regulator and therapeutic target in osteoarthritis (OA). Functional Nav1.7 expression was identified in human OA-associated chondrocytes and shown in several genetic mouse models to promote disease progression. Thus, targeting and modulating it, including pharmacologically, could represent a previously unexplored avenue for developing therapeutic interventions to manage the disease. This study further highlights the need to understand the chondrocyte “channelome” more completely to unravel the diverse roles of ion channels in cartilage homeostasis and their clinical potential.

KW - chondrocyte

KW - ion channel

KW - metabolic regulation

KW - Na1.7

KW - osteoarthritis

KW - therapeutic target

UR - http://www.scopus.com/inward/record.url?scp=85188562620&partnerID=8YFLogxK

U2 - 10.1089/bioe.2024.0013

DO - 10.1089/bioe.2024.0013

M3 - Review article

AN - SCOPUS:85188562620

SN - 2576-3105

VL - 6

SP - 54

EP - 56

JO - Bioelectricity

JF - Bioelectricity

IS - 1

ER -

Ion Channels As Emerging Metabolic Regulators and Therapeutic Targets in Osteoarthritis: Nav1.7 As a Recent Exemplar

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this