The extremotolerant isolate H45 was one of several actinomycetes isolated from a high-altitude Atacama Desert soil collected in northwest Chile. The isolate was identified as a new Lentzea sp. using a combination of chemotaxonomic, morphological and phylogenetic properties. Large scale fermentation of the strain in two different media followed by chromatographic purification led to the isolation of six new diene and monoene glycosides named lentzeosides A-F, together with the known compound (Z)-3-hexenyl glucoside. The structures of the new compounds were confirmed by HRESIMS and NMR analyses. Compounds 1-6 displayed moderate inhibitory activity against HIV integrase.
We thank the College of Physical Sciences, University of Aberdeen, for provision of infrastructure and facilities in the Marine Biodiscovery Centre, and staff at the European Southern Observatory for permission and assistance in collecting soil samples from the Chajnantor plateau. A.T.B and J.A.A thank The Royal Society for support (International Joint Project Grant JP 100654). JAA thanks Conicyt for the Basal Grant FB0001 for the Centre CeBiB. H.I. is grateful for a scholarship from the Malaysian Government and M.G. for an Emeritus Fellowship from the Leverhulme Trust.