Isolation and anti-HIV-1 integrase activity of lentzeosides A-F from extremotolerant lentzea sp. H45, a strain isolated from a high-altitude Atacama Desert soil

Dominik Wichner; Hamidah Idris; Wael E. Houssen; Andrew R. McEwan; Alan T. Bull; Juan A. Asenjo; Michael Goodfellow; Marcel Jaspars; Rainer Ebel; Mostafa E. Rateb

doi:10.1038/ja.2016.78

Isolation and anti-HIV-1 integrase activity of lentzeosides A-F from extremotolerant lentzea sp. H45, a strain isolated from a high-altitude Atacama Desert soil

Dominik Wichner, Hamidah Idris, Wael E. Houssen, Andrew R. McEwan, Alan T. Bull, Juan A. Asenjo, Michael Goodfellow, Marcel Jaspars, Rainer Ebel, Mostafa E. Rateb

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Abstract

The extremotolerant isolate H45 was one of several actinomycetes isolated from a high-altitude Atacama Desert soil collected in northwest Chile. The isolate was identified as a new Lentzea sp. using a combination of chemotaxonomic, morphological and phylogenetic properties. Large scale fermentation of the strain in two different media followed by chromatographic purification led to the isolation of six new diene and monoene glycosides named lentzeosides A-F, together with the known compound (Z)-3-hexenyl glucoside. The structures of the new compounds were confirmed by HRESIMS and NMR analyses. Compounds 1-6 displayed moderate inhibitory activity against HIV integrase.

Original language	English
Pages (from-to)	448-453
Number of pages	6
Journal	The Journal of antibiotics
Volume	70
Early online date	29 Jun 2016
DOIs	https://doi.org/10.1038/ja.2016.78
Publication status	Published - Apr 2017

Bibliographical note

ACKNOWLEDGEMENTS
We thank the College of Physical Sciences, University of Aberdeen, for provision of infrastructure and facilities in the Marine Biodiscovery Centre, and staff at the European Southern Observatory for permission and assistance in collecting soil samples from the Chajnantor plateau. A.T.B and J.A.A thank The Royal Society for support (International Joint Project Grant JP 100654). JAA thanks Conicyt for the Basal Grant FB0001 for the Centre CeBiB. H.I. is grateful for a scholarship from the Malaysian Government and M.G. for an Emeritus Fellowship from the Leverhulme Trust.

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Rainer Ebel
- School of Natural & Computing Sciences, Chemistry - Personal Chair
Person: Academic

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Wichner, D., Idris, H., Houssen, W. E., McEwan, A. R., Bull, A. T., Asenjo, J. A., Goodfellow, M., Jaspars, M., Ebel, R., & Rateb, M. E. (2017). Isolation and anti-HIV-1 integrase activity of lentzeosides A-F from extremotolerant lentzea sp. H45, a strain isolated from a high-altitude Atacama Desert soil. The Journal of antibiotics, 70, 448-453. https://doi.org/10.1038/ja.2016.78

Wichner, D, Idris, H, Houssen, WE , McEwan, AR, Bull, AT, Asenjo, JA, Goodfellow, M, Jaspars, M , Ebel, R & Rateb, ME 2017, 'Isolation and anti-HIV-1 integrase activity of lentzeosides A-F from extremotolerant lentzea sp. H45, a strain isolated from a high-altitude Atacama Desert soil', The Journal of antibiotics, vol. 70, pp. 448-453. https://doi.org/10.1038/ja.2016.78

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title = "Isolation and anti-HIV-1 integrase activity of lentzeosides A-F from extremotolerant lentzea sp. H45, a strain isolated from a high-altitude Atacama Desert soil",

abstract = "The extremotolerant isolate H45 was one of several actinomycetes isolated from a high-altitude Atacama Desert soil collected in northwest Chile. The isolate was identified as a new Lentzea sp. using a combination of chemotaxonomic, morphological and phylogenetic properties. Large scale fermentation of the strain in two different media followed by chromatographic purification led to the isolation of six new diene and monoene glycosides named lentzeosides A-F, together with the known compound (Z)-3-hexenyl glucoside. The structures of the new compounds were confirmed by HRESIMS and NMR analyses. Compounds 1-6 displayed moderate inhibitory activity against HIV integrase.",

author = "Dominik Wichner and Hamidah Idris and Houssen, {Wael E.} and McEwan, {Andrew R.} and Bull, {Alan T.} and Asenjo, {Juan A.} and Michael Goodfellow and Marcel Jaspars and Rainer Ebel and Rateb, {Mostafa E.}",

note = "ACKNOWLEDGEMENTS We thank the College of Physical Sciences, University of Aberdeen, for provision of infrastructure and facilities in the Marine Biodiscovery Centre, and staff at the European Southern Observatory for permission and assistance in collecting soil samples from the Chajnantor plateau. A.T.B and J.A.A thank The Royal Society for support (International Joint Project Grant JP 100654). JAA thanks Conicyt for the Basal Grant FB0001 for the Centre CeBiB. H.I. is grateful for a scholarship from the Malaysian Government and M.G. for an Emeritus Fellowship from the Leverhulme Trust. ",

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AB - The extremotolerant isolate H45 was one of several actinomycetes isolated from a high-altitude Atacama Desert soil collected in northwest Chile. The isolate was identified as a new Lentzea sp. using a combination of chemotaxonomic, morphological and phylogenetic properties. Large scale fermentation of the strain in two different media followed by chromatographic purification led to the isolation of six new diene and monoene glycosides named lentzeosides A-F, together with the known compound (Z)-3-hexenyl glucoside. The structures of the new compounds were confirmed by HRESIMS and NMR analyses. Compounds 1-6 displayed moderate inhibitory activity against HIV integrase.

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Isolation and anti-HIV-1 integrase activity of lentzeosides A-F from extremotolerant lentzea sp. H45, a strain isolated from a high-altitude Atacama Desert soil

Abstract

Bibliographical note

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