Kinkhoest bij jonge zuigelingen: een gevaarlijke ziekte met aspecifieke verschijnselen

Translated title of the contribution: Whooping cough in young infants: a dangerous disease with non-specific signs

Judith E. Nooitgedagt, Adilia Warris, K. D. Djiem Liem, Louis van 't Hek, Stefanie S. Henriet

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Pertussis, or whooping cough, caused by Bordetella pertussis, still occurs despite vaccination. Most of the cases occurring in adolescents and adults are mild or have a subclinical course, but these patients can be a source of transmission to unvaccinated or partially vaccinated infants. Symptoms of infant pertussis are often not specific, but pertussis can be fatal. In this article, we present one case of unvaccinated twins who each presented with initial signs of a viral respiratory disease. Within a few days, each developed rapidly progressive respiratory failure complicated by refractory pulmonary hypertension due to malignant pertussis. Both patients died eventually. It is important for paediatricians, general practitioners, midwives and gynaecologists to be alert to coughing in their patients. More efficient vaccination strategies should be discussed to prevent both the transmission of B. pertussis and the occurrence of severe and fatal pertussis in young infants.

Translated title of the contributionWhooping cough in young infants: a dangerous disease with non-specific signs
Original languageOther
Article numberA5573
JournalNederlands tijdschrift voor geneeskunde
Issue number4
Publication statusPublished - 22 Jan 2013


  • Bordetella pertussis
  • Fatal Outcome
  • Female
  • Humans
  • Infant
  • Male
  • Pertussis Vaccine
  • Sudden Infant Death
  • Vaccination
  • Whooping Cough
  • Case Reports
  • English Abstract
  • Journal Article


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