Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4

Pamela Sklar, Stephan Ripke, Laura J Scott, Ole A Andreassen, Sven Cichon, Nick Craddock, Howard J Edenberg, John I Nurnberger, Marcella Rietschel, Douglas Blackwood, Aiden Corvin, Matthew Flickinger, Weihua Guan, Morten Mattingsdal, Andrew McQuillin, Phoenix Kwan, Thomas F Wienker, Mark Daly, Frank Dudbridge, Peter A HolmansDanyu Lin, Margit Burmeister, Tiffany A Greenwood, Marian L Hamshere, Pierandrea Muglia, Erin N Smith, Peter P Zandi, Caroline M Nievergelt, Rebecca McKinney, Paul D Shilling, Nicholas J Schork, Cinnamon S Bloss, Tatiana Foroud, Daniel L Koller, Elliot S Gershon, Chunyu Liu, Judith A Badner, William A Scheftner, William B Lawson, Evaristus A Nwulia, Maria Hipolito, William Coryell, John Rice, William Byerley, Francis J McMahon, Thomas G Schulze, Wade Berrettini, Jun Li, Gerome Breen, David St Clair, Psychiatric GWAS Consortium Bipolar Disorder Working Group

Research output: Contribution to journalArticlepeer-review

1068 Citations (Scopus)


We conducted a combined genome-wide association study (GWAS) of 7,481 individuals with bipolar disorder (cases) and 9,250 controls as part of the Psychiatric GWAS Consortium. Our replication study tested 34 SNPs in 4,496 independent cases with bipolar disorder and 42,422 independent controls and found that 18 of 34 SNPs had P <0.05, with 31 of 34 SNPs having signals with the same direction of effect (P = 3.8 × 10(-7)). An analysis of all 11,974 bipolar disorder cases and 51,792 controls confirmed genome-wide significant evidence of association for CACNA1C and identified a new intronic variant in ODZ4. We identified a pathway comprised of subunits of calcium channels enriched in bipolar disorder association intervals. Finally, a combined GWAS analysis of schizophrenia and bipolar disorder yielded strong association evidence for SNPs in CACNA1C and in the region of NEK4-ITIH1-ITIH3-ITIH4. Our replication results imply that increasing sample sizes in bipolar disorder will confirm many additional loci.
Original languageEnglish
Pages (from-to)977-983
Number of pages7
JournalNature Genetics
Issue number10
Publication statusPublished - Oct 2011


  • alleles
  • bipolar disorder
  • calcium channels, L-type
  • case-control studies
  • databases, genetic
  • genetic loci
  • genetic predisposition to disease
  • genome, human
  • genome-wide association study
  • humans
  • linkage disequilibrium
  • nuclear proteins
  • polymorphism, single nucleotide
  • schizophrenia


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