Abstract
In a chemical screening of fungal strains endophytic to Nigerian plants, Diaporthe phaseolorum, the endophyte of Bryophyllum pinnatum, gave cytochalasin D and (3R,4R)-3,4,5-trihydroxy-1-tetralone, Neurospora discreta from Morinda lucida yielded multiforisin I and 4-hydroxyphenylacetic acid, while Aspergillus japonicus from Jatropha gossypiifolia gave (+)-eupenoxide and microsphaerone C, a new 4-pyridone derivative. When tested for cytotoxic activity, cytochalasin D displayed strong, activity towards the mouse lymphoma cell line L5178Y, while the remaining compounds, except 4-hydroxyphenylacetic acid, were found to be moderately active.
Original language | English |
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Pages (from-to) | 1217-1222 |
Number of pages | 6 |
Journal | Natural Product Communications |
Volume | 3 |
DOIs | |
Publication status | Published - 2008 |
Keywords
- endophytic fungi
- diaporthe phaseolorum
- neurospora discreta
- aspergillus japonicus
- microsphaerone C
- cytotoxicity
- marine-derived fungus
- 4-hydroxyphenylacetic acid
- diaporthe SP
- metabolites
- degradation
- derivatives
- continuum