Maternal body mass index in pregnancy and mental disorders in adult offspring: a record linkage study in Aberdeen, Scotland

Marius Lahti-Pulkkinen; Katri Räikkönen; Sohinee Bhattacharya; Rebecca M. Reynolds

doi:10.1038/s41598-021-94511-y

Maternal body mass index in pregnancy and mental disorders in adult offspring: a record linkage study in Aberdeen, Scotland

Marius Lahti-Pulkkinen^* (Corresponding Author), Katri Räikkönen, Sohinee Bhattacharya, Rebecca M. Reynolds

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

10 Downloads (Pure)

Abstract

Maternal obesity in pregnancy predicts offspring psychopathology risk in childhood but it remains unclear whether maternal obesity or underweight associate with adult offspring mental disorders. We examined longitudinally whether maternal body mass index (BMI) in pregnancy predicted mental disorders in her offspring and whether the associations differed by offspring birth year among 68,571 mother–child dyads of Aberdeen Maternity and Neonatal Databank, Scotland. The offspring were born 1950–1999. Maternal BMI was measured at a mean 15.7 gestational weeks and classified into underweight, normal weight, overweight, moderate obesity and severe obesity. Mental disorders were identified from nationwide registers carrying diagnoses of all hospitalizations and deaths in Scotland in 1996–2017. We found that maternal BMI in pregnancy was associated with offspring mental disorders in a time-dependent manner: In offspring born 1950–1974, maternal underweight predicted an increased hazard of mental disorders [Hazard Ratio (HR) = 1.74; 95% Confidence Interval (CI) = 1.01–3.00)]. In offspring born 1975–1999, maternal severe obesity predicted increased hazards of any mental (HR 1.60; 95% CI 1.08–2.38) substance use (HR 1.91; 95% CI 1.03–3.57) and schizophrenia spectrum (HR 2.80; 95% CI 1.40–5.63) disorders. Our findings of time-specific associations between maternal prenatal BMI and adult offspring mental disorders may carry important public health implications by underlining possible lifelong effects of maternal BMI on offspring psychopathology.

Original language	English
Article number	15132
Number of pages	13
Journal	Scientific Reports
Volume	11
Issue number	1
Early online date	23 Jul 2021
DOIs	https://doi.org/10.1038/s41598-021-94511-y
Publication status	Published - 23 Jul 2021

Bibliographical note

Acknowledgements
This work was supported by the Academy of Finland (grant numbers 285324, 12848591, 1284859, 1312670, 269925, 336209), European Commission EraNet Neuron, University of Helsinki Funds, British Heart Foundation, and Tommy’s. The funders played no role in the planning, conduct or design of the study.

Funding
This work was supported by the Academy of Finland (grant numbers 330206, 285324, 12848591, 1284859, 1312670, 269925), European Commission EraNet Neuron, University of Helsinki Funds, British Heart Foundation, and Tommy’s.

Keywords

endocrinology
epidemiology
medical research
psychology
risk factors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/s41598-021-94511-yLicence: CC BY

Pulkkinen_etal_SR_Maternal_Body_Mass_VoR
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
Final published version, 1.13 MBLicence: CC BY

Aberdeen Maternity and Neonatal Databank
Bhattacharya, S. (Data Manager) & Wilde, K. J. (Supervisor), University of Aberdeen, 1986
http://www.abdn.ac.uk/iahs/research/obsgynae/amnd/overview.php and one more link, http://www.abdn.ac.uk/iahs/research/obsgynae/amnd/access.php (show fewer)
Dataset

Cite this

@article{6c4a30184f4b4353af226941439aa452,

title = "Maternal body mass index in pregnancy and mental disorders in adult offspring: a record linkage study in Aberdeen, Scotland",

abstract = "Maternal obesity in pregnancy predicts offspring psychopathology risk in childhood but it remains unclear whether maternal obesity or underweight associate with adult offspring mental disorders. We examined longitudinally whether maternal body mass index (BMI) in pregnancy predicted mental disorders in her offspring and whether the associations differed by offspring birth year among 68,571 mother–child dyads of Aberdeen Maternity and Neonatal Databank, Scotland. The offspring were born 1950–1999. Maternal BMI was measured at a mean 15.7 gestational weeks and classified into underweight, normal weight, overweight, moderate obesity and severe obesity. Mental disorders were identified from nationwide registers carrying diagnoses of all hospitalizations and deaths in Scotland in 1996–2017. We found that maternal BMI in pregnancy was associated with offspring mental disorders in a time-dependent manner: In offspring born 1950–1974, maternal underweight predicted an increased hazard of mental disorders [Hazard Ratio (HR) = 1.74; 95% Confidence Interval (CI) = 1.01–3.00)]. In offspring born 1975–1999, maternal severe obesity predicted increased hazards of any mental (HR 1.60; 95% CI 1.08–2.38) substance use (HR 1.91; 95% CI 1.03–3.57) and schizophrenia spectrum (HR 2.80; 95% CI 1.40–5.63) disorders. Our findings of time-specific associations between maternal prenatal BMI and adult offspring mental disorders may carry important public health implications by underlining possible lifelong effects of maternal BMI on offspring psychopathology.",

keywords = "endocrinology, epidemiology, medical research, psychology, risk factors",

author = "Marius Lahti-Pulkkinen and Katri R{\"a}ikk{\"o}nen and Sohinee Bhattacharya and Reynolds, {Rebecca M.}",

note = "Acknowledgements This work was supported by the Academy of Finland (grant numbers 285324, 12848591, 1284859, 1312670, 269925, 336209), European Commission EraNet Neuron, University of Helsinki Funds, British Heart Foundation, and Tommy{\textquoteright}s. The funders played no role in the planning, conduct or design of the study. Funding This work was supported by the Academy of Finland (grant numbers 330206, 285324, 12848591, 1284859, 1312670, 269925), European Commission EraNet Neuron, University of Helsinki Funds, British Heart Foundation, and Tommy{\textquoteright}s.",

year = "2021",

month = jul,

day = "23",

doi = "10.1038/s41598-021-94511-y",

language = "English",

volume = "11",

journal = "Scientific Reports",

issn = "2045-2322",

publisher = "Nature Publishing Group",

number = "1",

}

TY - JOUR

T1 - Maternal body mass index in pregnancy and mental disorders in adult offspring

T2 - a record linkage study in Aberdeen, Scotland

AU - Lahti-Pulkkinen, Marius

AU - Räikkönen, Katri

AU - Bhattacharya, Sohinee

AU - Reynolds, Rebecca M.

N1 - Acknowledgements This work was supported by the Academy of Finland (grant numbers 285324, 12848591, 1284859, 1312670, 269925, 336209), European Commission EraNet Neuron, University of Helsinki Funds, British Heart Foundation, and Tommy’s. The funders played no role in the planning, conduct or design of the study. Funding This work was supported by the Academy of Finland (grant numbers 330206, 285324, 12848591, 1284859, 1312670, 269925), European Commission EraNet Neuron, University of Helsinki Funds, British Heart Foundation, and Tommy’s.

PY - 2021/7/23

Y1 - 2021/7/23

N2 - Maternal obesity in pregnancy predicts offspring psychopathology risk in childhood but it remains unclear whether maternal obesity or underweight associate with adult offspring mental disorders. We examined longitudinally whether maternal body mass index (BMI) in pregnancy predicted mental disorders in her offspring and whether the associations differed by offspring birth year among 68,571 mother–child dyads of Aberdeen Maternity and Neonatal Databank, Scotland. The offspring were born 1950–1999. Maternal BMI was measured at a mean 15.7 gestational weeks and classified into underweight, normal weight, overweight, moderate obesity and severe obesity. Mental disorders were identified from nationwide registers carrying diagnoses of all hospitalizations and deaths in Scotland in 1996–2017. We found that maternal BMI in pregnancy was associated with offspring mental disorders in a time-dependent manner: In offspring born 1950–1974, maternal underweight predicted an increased hazard of mental disorders [Hazard Ratio (HR) = 1.74; 95% Confidence Interval (CI) = 1.01–3.00)]. In offspring born 1975–1999, maternal severe obesity predicted increased hazards of any mental (HR 1.60; 95% CI 1.08–2.38) substance use (HR 1.91; 95% CI 1.03–3.57) and schizophrenia spectrum (HR 2.80; 95% CI 1.40–5.63) disorders. Our findings of time-specific associations between maternal prenatal BMI and adult offspring mental disorders may carry important public health implications by underlining possible lifelong effects of maternal BMI on offspring psychopathology.

AB - Maternal obesity in pregnancy predicts offspring psychopathology risk in childhood but it remains unclear whether maternal obesity or underweight associate with adult offspring mental disorders. We examined longitudinally whether maternal body mass index (BMI) in pregnancy predicted mental disorders in her offspring and whether the associations differed by offspring birth year among 68,571 mother–child dyads of Aberdeen Maternity and Neonatal Databank, Scotland. The offspring were born 1950–1999. Maternal BMI was measured at a mean 15.7 gestational weeks and classified into underweight, normal weight, overweight, moderate obesity and severe obesity. Mental disorders were identified from nationwide registers carrying diagnoses of all hospitalizations and deaths in Scotland in 1996–2017. We found that maternal BMI in pregnancy was associated with offspring mental disorders in a time-dependent manner: In offspring born 1950–1974, maternal underweight predicted an increased hazard of mental disorders [Hazard Ratio (HR) = 1.74; 95% Confidence Interval (CI) = 1.01–3.00)]. In offspring born 1975–1999, maternal severe obesity predicted increased hazards of any mental (HR 1.60; 95% CI 1.08–2.38) substance use (HR 1.91; 95% CI 1.03–3.57) and schizophrenia spectrum (HR 2.80; 95% CI 1.40–5.63) disorders. Our findings of time-specific associations between maternal prenatal BMI and adult offspring mental disorders may carry important public health implications by underlining possible lifelong effects of maternal BMI on offspring psychopathology.

KW - endocrinology

KW - epidemiology

KW - medical research

KW - psychology

KW - risk factors

U2 - 10.1038/s41598-021-94511-y

DO - 10.1038/s41598-021-94511-y

M3 - Article

C2 - 34302021

SN - 2045-2322

VL - 11

JO - Scientific Reports

JF - Scientific Reports

IS - 1

M1 - 15132

ER -

Maternal body mass index in pregnancy and mental disorders in adult offspring: a record linkage study in Aberdeen, Scotland

Abstract

Bibliographical note

Keywords

UN SDGs

Access to Document

Fingerprint

Datasets

Aberdeen Maternity and Neonatal Databank

Cite this