Maternal High Fat Diet in Lactation Impacts Hypothalamic Neurogenesis and Neurotrophic Development, Leading to Later Life Susceptibility to Obesity in Male but Not Female Mice

Yanchao Xu; Dengbao Yang; Lu Wang; Elżbieta Król; Mohsen Mazidi; Li Li; Yi Huang; Chaoqun Niu; Xue Liu; Sin Man Lam; Guanghou Shui; Alex Douglas; John R Speakman

doi:10.1002/advs.202305472

Maternal High Fat Diet in Lactation Impacts Hypothalamic Neurogenesis and Neurotrophic Development, Leading to Later Life Susceptibility to Obesity in Male but Not Female Mice

Yanchao Xu, Dengbao Yang, Lu Wang, Elżbieta Król, Mohsen Mazidi, Li Li, Yi Huang, Chaoqun Niu, Xue Liu, Sin Man Lam, Guanghou Shui, Alex Douglas, John R Speakman

Research output: Contribution to journal › Article › peer-review

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Abstract

Early life nutrition can reprogram development and exert long-term consequences on body weight regulation. In mice, maternal high-fat diet (HFD) during lactation predisposed male but not female offspring to diet-induced obesity when adult. Molecular and cellular changes in the hypothalamus at important time points are examined in the early postnatal life in relation to maternal diet and demonstrated sex-differential hypothalamic reprogramming. Maternal HFD in lactation decreased the neurotropic development of neurons formed at the embryo stage (e12.5) and impaired early postnatal neurogenesis in the hypothalamic regions of both males and females. Males show a larger increased ratio of Neuropeptide Y (NPY) to Pro-opiomelanocortin (POMC) neurons in early postnatal neurogenesis, in response to maternal HFD, setting an obese tone for male offspring. These data provide insights into the mechanisms by which hypothalamic reprograming by early life overnutrition contributes to the sex-dependent susceptibility to obesity in adult life in mice.

Original language	English
Article number	e2305472
Journal	Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Early online date	22 Oct 2023
DOIs	https://doi.org/10.1002/advs.202305472
Publication status	E-pub ahead of print - 22 Oct 2023

Bibliographical note

Research Funding
National Key Research and Development Program of China. Grant Number: 2018YFA0801000
National Natural Science Foundation of China. Grant Number: 92057206
A Wolfson merit professorship from UK Royal Society
Postdoctoral Research Foundation of China. Grant Numbers: 2013M540157, 2014T70135
The KC Wong Education Foundation
Grants from the "1000 talents" recruitment program
A PIFI professional fellowship from CAS

Data Availability Statement

The data that support the findings of this study are available from the corresponding author upon reasonable request.

Keywords

hypothalamic reprogramming
lactation
maternal high-fat diet
neurogenesis
sex-differential offspring obesity

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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© 2023 The Authors. Advanced Science published by Wiley-VCH GmbH This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Final published version, 5.76 MBLicence: CC BY

Cite this

Xu, Y., Yang, D., Wang, L., Król, E., Mazidi, M., Li, L., Huang, Y., Niu, C., Liu, X., Lam, S. M., Shui, G., Douglas, A., & Speakman, J. R. (2023). Maternal High Fat Diet in Lactation Impacts Hypothalamic Neurogenesis and Neurotrophic Development, Leading to Later Life Susceptibility to Obesity in Male but Not Female Mice. Advanced science (Weinheim, Baden-Wurttemberg, Germany), Article e2305472. Advance online publication. https://doi.org/10.1002/advs.202305472

Xu, Y, Yang, D, Wang, L, Król, E, Mazidi, M, Li, L, Huang, Y, Niu, C, Liu, X, Lam, SM, Shui, G, Douglas, A & Speakman, JR 2023, 'Maternal High Fat Diet in Lactation Impacts Hypothalamic Neurogenesis and Neurotrophic Development, Leading to Later Life Susceptibility to Obesity in Male but Not Female Mice', Advanced science (Weinheim, Baden-Wurttemberg, Germany). https://doi.org/10.1002/advs.202305472

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abstract = "Early life nutrition can reprogram development and exert long-term consequences on body weight regulation. In mice, maternal high-fat diet (HFD) during lactation predisposed male but not female offspring to diet-induced obesity when adult. Molecular and cellular changes in the hypothalamus at important time points are examined in the early postnatal life in relation to maternal diet and demonstrated sex-differential hypothalamic reprogramming. Maternal HFD in lactation decreased the neurotropic development of neurons formed at the embryo stage (e12.5) and impaired early postnatal neurogenesis in the hypothalamic regions of both males and females. Males show a larger increased ratio of Neuropeptide Y (NPY) to Pro-opiomelanocortin (POMC) neurons in early postnatal neurogenesis, in response to maternal HFD, setting an obese tone for male offspring. These data provide insights into the mechanisms by which hypothalamic reprograming by early life overnutrition contributes to the sex-dependent susceptibility to obesity in adult life in mice.",

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AU - Xu, Yanchao

AU - Yang, Dengbao

AU - Wang, Lu

AU - Król, Elżbieta

AU - Mazidi, Mohsen

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AU - Huang, Yi

AU - Niu, Chaoqun

AU - Liu, Xue

AU - Lam, Sin Man

AU - Shui, Guanghou

AU - Douglas, Alex

AU - Speakman, John R

N1 - Research Funding National Key Research and Development Program of China. Grant Number: 2018YFA0801000 National Natural Science Foundation of China. Grant Number: 92057206 A Wolfson merit professorship from UK Royal Society Postdoctoral Research Foundation of China. Grant Numbers: 2013M540157, 2014T70135 The KC Wong Education Foundation Grants from the "1000 talents" recruitment program A PIFI professional fellowship from CAS

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N2 - Early life nutrition can reprogram development and exert long-term consequences on body weight regulation. In mice, maternal high-fat diet (HFD) during lactation predisposed male but not female offspring to diet-induced obesity when adult. Molecular and cellular changes in the hypothalamus at important time points are examined in the early postnatal life in relation to maternal diet and demonstrated sex-differential hypothalamic reprogramming. Maternal HFD in lactation decreased the neurotropic development of neurons formed at the embryo stage (e12.5) and impaired early postnatal neurogenesis in the hypothalamic regions of both males and females. Males show a larger increased ratio of Neuropeptide Y (NPY) to Pro-opiomelanocortin (POMC) neurons in early postnatal neurogenesis, in response to maternal HFD, setting an obese tone for male offspring. These data provide insights into the mechanisms by which hypothalamic reprograming by early life overnutrition contributes to the sex-dependent susceptibility to obesity in adult life in mice.

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Maternal High Fat Diet in Lactation Impacts Hypothalamic Neurogenesis and Neurotrophic Development, Leading to Later Life Susceptibility to Obesity in Male but Not Female Mice

Abstract

Bibliographical note

Data Availability Statement

Keywords

UN SDGs

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