Mechanical adaptation of trabecular bone morphology in the mammalian mandible

Peter J. Watson; Laura C. Fitton; Carlos Meloro; Michael J. Fagan; Flora Gröning

doi:10.1038/s41598-018-25597-0

Mechanical adaptation of trabecular bone morphology in the mammalian mandible

Peter J. Watson, Laura C. Fitton, Carlos Meloro, Michael J. Fagan, Flora Gröning

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Abstract

Alveolar bone, together with the underlying trabecular bone, fulfils an important role in providing structural support against masticatory forces. Diseases such as osteoporosis or periodontitis cause alveolar bone resorption which weakens this structural support and is a major cause of tooth loss. However, the functional relationship between alveolar bone remodelling within the molar region and masticatory forces is not well understood. This study investigated this relationship by comparing mammalian species with different diets and functional loading (Felis catus, Cercocebus atys, Homo sapiens, Sus scrofa, Oryctolagus cuniculus, Ovis aries). We performed histomorphometric analyses of trabecular bone morphology (bone volume fraction, trabecular thickness and trabecular spacing) and quantified the variation of bone and tooth root volumes along the tooth row. A principal component analysis and non-parametric MANOVA showed statistically significant differences in trabecular bone morphology between species with contrasting functional loading, but these differences were not seen in sub-adult specimens. Our results support a strong, but complex link between masticatory function and trabecular bone morphology. Further understanding of a potential functional relationship could aid the diagnosis and treatment of mandibular diseases causing alveolar bone resorption, and guide the design and evaluation of dental implants.

Original language	English
Article number	7277
Journal	Scientific Reports
Volume	8
DOIs	https://doi.org/10.1038/s41598-018-25597-0
Publication status	Published - 8 May 2018

Bibliographical note

Funding statement
This research was supported by BBSRC grant (BB/I008462/1) and Marie Curie Actions Integration grant (FP7-PEOPLE PERG7-GA-2010-268430).

Acknowledgements
The authors would like to Sue Taft (University of Hull) for performing all µCT-scanning, Sue Black (University of Dundee) for providing the human mandibles, Paul O’Higgins (Hull York Medical School) for the mangabey mandibles, and the Institute of Veterinary Science and Nathan Jeffery (both University of Liverpool) for the cat mandibles used in this study.

Keywords

biomedical engineering
oral anatomy

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Mechanical adaptation of trabecular bone morphology in the mammalian mandible
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Flora Gröning
Person: Academic

Cite this

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title = "Mechanical adaptation of trabecular bone morphology in the mammalian mandible",

abstract = "Alveolar bone, together with the underlying trabecular bone, fulfils an important role in providing structural support against masticatory forces. Diseases such as osteoporosis or periodontitis cause alveolar bone resorption which weakens this structural support and is a major cause of tooth loss. However, the functional relationship between alveolar bone remodelling within the molar region and masticatory forces is not well understood. This study investigated this relationship by comparing mammalian species with different diets and functional loading (Felis catus, Cercocebus atys, Homo sapiens, Sus scrofa, Oryctolagus cuniculus, Ovis aries). We performed histomorphometric analyses of trabecular bone morphology (bone volume fraction, trabecular thickness and trabecular spacing) and quantified the variation of bone and tooth root volumes along the tooth row. A principal component analysis and non-parametric MANOVA showed statistically significant differences in trabecular bone morphology between species with contrasting functional loading, but these differences were not seen in sub-adult specimens. Our results support a strong, but complex link between masticatory function and trabecular bone morphology. Further understanding of a potential functional relationship could aid the diagnosis and treatment of mandibular diseases causing alveolar bone resorption, and guide the design and evaluation of dental implants.",

keywords = "biomedical engineering, oral anatomy ",

author = "Watson, {Peter J.} and Fitton, {Laura C.} and Carlos Meloro and Fagan, {Michael J.} and Flora Gr{\"o}ning",

note = "Funding statement This research was supported by BBSRC grant (BB/I008462/1) and Marie Curie Actions Integration grant (FP7-PEOPLE PERG7-GA-2010-268430). Acknowledgements The authors would like to Sue Taft (University of Hull) for performing all µCT-scanning, Sue Black (University of Dundee) for providing the human mandibles, Paul O{\textquoteright}Higgins (Hull York Medical School) for the mangabey mandibles, and the Institute of Veterinary Science and Nathan Jeffery (both University of Liverpool) for the cat mandibles used in this study.",

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AU - Gröning, Flora

N1 - Funding statement This research was supported by BBSRC grant (BB/I008462/1) and Marie Curie Actions Integration grant (FP7-PEOPLE PERG7-GA-2010-268430). Acknowledgements The authors would like to Sue Taft (University of Hull) for performing all µCT-scanning, Sue Black (University of Dundee) for providing the human mandibles, Paul O’Higgins (Hull York Medical School) for the mangabey mandibles, and the Institute of Veterinary Science and Nathan Jeffery (both University of Liverpool) for the cat mandibles used in this study.

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N2 - Alveolar bone, together with the underlying trabecular bone, fulfils an important role in providing structural support against masticatory forces. Diseases such as osteoporosis or periodontitis cause alveolar bone resorption which weakens this structural support and is a major cause of tooth loss. However, the functional relationship between alveolar bone remodelling within the molar region and masticatory forces is not well understood. This study investigated this relationship by comparing mammalian species with different diets and functional loading (Felis catus, Cercocebus atys, Homo sapiens, Sus scrofa, Oryctolagus cuniculus, Ovis aries). We performed histomorphometric analyses of trabecular bone morphology (bone volume fraction, trabecular thickness and trabecular spacing) and quantified the variation of bone and tooth root volumes along the tooth row. A principal component analysis and non-parametric MANOVA showed statistically significant differences in trabecular bone morphology between species with contrasting functional loading, but these differences were not seen in sub-adult specimens. Our results support a strong, but complex link between masticatory function and trabecular bone morphology. Further understanding of a potential functional relationship could aid the diagnosis and treatment of mandibular diseases causing alveolar bone resorption, and guide the design and evaluation of dental implants.

AB - Alveolar bone, together with the underlying trabecular bone, fulfils an important role in providing structural support against masticatory forces. Diseases such as osteoporosis or periodontitis cause alveolar bone resorption which weakens this structural support and is a major cause of tooth loss. However, the functional relationship between alveolar bone remodelling within the molar region and masticatory forces is not well understood. This study investigated this relationship by comparing mammalian species with different diets and functional loading (Felis catus, Cercocebus atys, Homo sapiens, Sus scrofa, Oryctolagus cuniculus, Ovis aries). We performed histomorphometric analyses of trabecular bone morphology (bone volume fraction, trabecular thickness and trabecular spacing) and quantified the variation of bone and tooth root volumes along the tooth row. A principal component analysis and non-parametric MANOVA showed statistically significant differences in trabecular bone morphology between species with contrasting functional loading, but these differences were not seen in sub-adult specimens. Our results support a strong, but complex link between masticatory function and trabecular bone morphology. Further understanding of a potential functional relationship could aid the diagnosis and treatment of mandibular diseases causing alveolar bone resorption, and guide the design and evaluation of dental implants.

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VL - 8

JO - Scientific Reports

JF - Scientific Reports

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Mechanical adaptation of trabecular bone morphology in the mammalian mandible

Abstract

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Keywords

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Flora Gröning

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