Mechanisms of Salmonella Typhi Host Restriction

Stefania Spanò

Research output: Chapter in Book/Report/Conference proceedingPublished conference contribution

14 Citations (Scopus)


Salmonella enterica serovar Typhi (S. Typhi) is the cause of typhoid fever, a life-threatening bacterial infection that is very common in the developing world. Recent spread of antimicrobial resistant isolates of S. Typhi makes typhoid fever, a global public health risk. Despite being a common disease, still very little is known about the molecular mechanisms underlying typhoid fever and S. Typhi pathogenesis. In contrast to other Salmonellae, S. Typhi can only infect humans. The molecular bases of this human restriction are mostly unknown. Recent studies identified a novel pathway that contributes to S. Typhi human restriction and is required for killing S. Typhi in macrophages of nonsusceptible species. The small Rab GTPase Rab32 and its guanine nucleotide exchange factor BLOC-3 are the critical components of this pathway. These proteins were already well known as important regulators of intracellular membrane transport. In particular, they are central for the transport of enzymes that synthetize melanin in pigment cells. The recent findings that Rab32 and BLOC-3 are required for S. Typhi host restriction point out to a novel mechanism restricting the growth of bacterial pathogen, dependent on the transport of still unknown molecule(s) to the S. Typhi vacuole. The identification of this novel antimicrobial pathway constitutes a critical starting point to study molecular mechanisms killing bacterial pathogens and possibly identify novel antimicrobial molecules.

Original languageEnglish
Title of host publicationBiophysics of Infection
EditorsMark C. Leake
PublisherSpringer International Publishing
Number of pages12
ISBN (Electronic)978-3-319-32189-9
ISBN (Print)978-3-319-32187-5
Publication statusPublished - 19 May 2016

Publication series

NameAdvances in Experimental Medicine and Biology
PublisherSpringer International Publishing
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019


  • Salmonella Typhi
  • Typhoid fever
  • Rab GTPases
  • Hermansky– Pudlak syndrome
  • Lysosome-related organelles
  • Host–pathogen interaction


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