Abstract
The relationship of neuropathology to CNS inflammatory and counter-inflammatory cytokine production in African trypanosome-infected mice was studied using an infection model with a defined disease progression. The initial phase of CNS infection by trypanosomes, where only mild neuropathology is evident, was characterised by high levels of IL-10 and IL-6. In the later phase of CNS infection and in a post-drug treatment model, moderate to severe neuropathology was associated with high levels of IFN-gamma and TNF-alpha. The relationship of these cytokines to neuropathological grade suggests that IL-10 and IL-6 protect the CNS from inflammatory pathology when parasites first enter the brain and the data reconcile previously contradictory clinical measurements of CSF cytokines in meningoencephalitic patients with postmortem histopathology observations. (C) 2005 Published by Elsevier B.V.
Original language | English |
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Pages (from-to) | 81-89 |
Number of pages | 8 |
Journal | Journal of Neuroimmunology |
Volume | 167 |
Issue number | 1-2 |
DOIs | |
Publication status | Published - Oct 2005 |
Keywords
- African trypanosomiasis
- meningoencephalitis
- cytokines
- IL-6
- IL-10
- TNF-alpha
- IFN-gamma
- nitric oxide
- CENTRAL-NERVOUS-SYSTEM
- CYTOKINE MESSENGER-RNA
- BRUCEI-INFECTED MICE
- SLEEPING SICKNESS
- NITRIC-OXIDE
- AUTOIMMUNE ENCEPHALOMYELITIS
- TOXOPLASMIC ENCEPHALITIS
- ENCEPHALOPATHY
- EXPRESSION
- IMMUNOPATHOLOGY