Metabolic maturation in the first 2 years of life in resource-constrained settings and its association with postnatal growths

N. Giallourou; F. Fardus-Reid; G. Panic; K. Veselkov; B. J.J. McCormick; M. P. Olortegui; T. Ahmed; E. Mduma; P. P. Yori; M. Mahfuz; E. Svensen; M. M.M. Ahmed; J. M. Colston; M. N. Kosek; J. R. Swann

doi:10.1126/sciadv.aay5969

Metabolic maturation in the first 2 years of life in resource-constrained settings and its association with postnatal growths

N. Giallourou, F. Fardus-Reid, G. Panic, K. Veselkov, B. J.J. McCormick, M. P. Olortegui, T. Ahmed, E. Mduma, P. P. Yori, M. Mahfuz, E. Svensen, M. M.M. Ahmed, J. M. Colston, M. N. Kosek^*, J. R. Swann

^*Corresponding author for this work

The Rowett Institute of Nutrition and Health

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Abstract

Malnutrition continues to affect the growth and development of millions of children worldwide, and chronic undernutrition has proven to be largely refractory to interventions. Improved understanding of metabolic development in infancy and how it differs in growth-constrained children may provide insights to inform more timely, targeted, and effective interventions. Here, the metabolome of healthy infants was compared to that of growth-constrained infants from three continents over the first 2 years of life to identify metabolic signatures of aging. Predictive models demonstrated that growth-constrained children lag in their metabolic maturity relative to their healthier peers and that metabolic maturity can predict growth 6 months into the future. Our results provide a metabolic framework from which future nutritional programs may be more precisely constructed and evaluated.

Original language	English
Article number	eaay5969
Number of pages	11
Journal	Science Advances
Volume	6
Issue number	15
Early online date	8 Apr 2020
DOIs	https://doi.org/10.1126/sciadv.aay5969
Publication status	Published - 8 Apr 2020

Bibliographical note

Funding Information:
The Etiology, Risk Factors, and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development Project (MAL-ED) is carried out as a collaborative project supported by the Bill & Melinda Gates Foundation (BMGF 47075), the Foundation for the National Institutes of Health, and the National Institutes of Health, Fogarty International Center, while additional support was obtained from BMGF for the examination of host innate factors on enteric disease risk and enteropathy (grants OPP1066146 and OPP1152146 to M.N.K.). Additional funding was obtained from the Sherrilyn and Ken Fisher Center for Environmental Infectious Diseases of the Johns Hopkins School of Medicine (to M.N.K.).

Publisher Copyright:
Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).

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Giallourou_et_al_metabolic_maturation_science_advances_vor
Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Cite this

Giallourou, N., Fardus-Reid, F., Panic, G., Veselkov, K., McCormick, B. J. J., Olortegui, M. P., Ahmed, T., Mduma, E., Yori, P. P., Mahfuz, M., Svensen, E., Ahmed, M. M. M., Colston, J. M., Kosek, M. N., & Swann, J. R. (2020). Metabolic maturation in the first 2 years of life in resource-constrained settings and its association with postnatal growths. Science Advances, 6(15), Article eaay5969. https://doi.org/10.1126/sciadv.aay5969

Giallourou, N, Fardus-Reid, F, Panic, G, Veselkov, K, McCormick, BJJ, Olortegui, MP, Ahmed, T, Mduma, E, Yori, PP, Mahfuz, M, Svensen, E, Ahmed, MMM, Colston, JM, Kosek, MN & Swann, JR 2020, 'Metabolic maturation in the first 2 years of life in resource-constrained settings and its association with postnatal growths', Science Advances, vol. 6, no. 15, eaay5969. https://doi.org/10.1126/sciadv.aay5969

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abstract = "Malnutrition continues to affect the growth and development of millions of children worldwide, and chronic undernutrition has proven to be largely refractory to interventions. Improved understanding of metabolic development in infancy and how it differs in growth-constrained children may provide insights to inform more timely, targeted, and effective interventions. Here, the metabolome of healthy infants was compared to that of growth-constrained infants from three continents over the first 2 years of life to identify metabolic signatures of aging. Predictive models demonstrated that growth-constrained children lag in their metabolic maturity relative to their healthier peers and that metabolic maturity can predict growth 6 months into the future. Our results provide a metabolic framework from which future nutritional programs may be more precisely constructed and evaluated.",

author = "N. Giallourou and F. Fardus-Reid and G. Panic and K. Veselkov and McCormick, {B. J.J.} and Olortegui, {M. P.} and T. Ahmed and E. Mduma and Yori, {P. P.} and M. Mahfuz and E. Svensen and Ahmed, {M. M.M.} and Colston, {J. M.} and Kosek, {M. N.} and Swann, {J. R.}",

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AU - McCormick, B. J.J.

AU - Olortegui, M. P.

AU - Ahmed, T.

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AU - Yori, P. P.

AU - Mahfuz, M.

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AU - Ahmed, M. M.M.

AU - Colston, J. M.

AU - Kosek, M. N.

AU - Swann, J. R.

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Metabolic maturation in the first 2 years of life in resource-constrained settings and its association with postnatal growths

Abstract

Bibliographical note

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