Metabolomics in antimicrobial drug discovery

Rustam Aminov* (Corresponding Author)

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Introduction
In light of the ever escalating problem of antimicrobial resistance, there is an urgent need for the development of new antimicrobials. In this review, the role of metabolomics in antimicrobial drug discovery and development is summarized and discussed. For this, ScienceDirect, PubMed, Web of Science and Google Scholar databases were searched with the article’s keywords and their combinations to retrieve the most relevant and up-to-date information.

Areas covered
The areas covered include the metabolomic concepts and techniques and bioinformatic tools used in metabolomics as well as recent developments in these areas. Also, examples of the use of metabolomics tools in several areas of antimicrobial drug discovery are given.

Expert opinion
Metabolomics, with the corresponding bioinformatic support and combination with other omics technologies, represents an integral and essential part of antimicrobial drug discovery and development. Metabolomics contributes to the mechanism-based approach in antimicrobial drug discovery, reveals the mechanisms of action of antimicrobials and non-antimicrobial compounds, identifies new targets, and opens new ways to manage and control bacterial infections.
Original languageEnglish
Pages (from-to)1047-1059
Number of pages13
JournalExpert Opinion on Drug Discovery
Volume17
Issue number9
Early online date13 Aug 2022
DOIs
Publication statusPublished - Sept 2022

Bibliographical note

Open Access via the Taylor & Francis Agreement

Keywords

  • metabolomics
  • antimicrobials
  • drug discovery
  • liquid chromatogrpahy
  • gas chromatography
  • mass spectrometry
  • nuclear magnetic resonance
  • metabolmics software
  • metabolomics database
  • ecosystem metabolomics

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