Methods for specifying the target difference in a randomised controlled trial: the Difference ELicitation in TriAls (DELTA) systematic review

Jenni Hislop; Temitope E Adewuyi; Luke D Vale; Kirsten Harrild; Cynthia Fraser; Tara Gurung; Douglas G Altman; Andrew H Briggs; Peter Fayers; Craig R Ramsay; John D Norrie; Ian M Harvey; Brian Buckley; Jonathan A Cook; DELTA group

doi:10.1371/journal.pmed.1001645

Methods for specifying the target difference in a randomised controlled trial: the Difference ELicitation in TriAls (DELTA) systematic review

Jenni Hislop, Temitope E Adewuyi, Luke D Vale, Kirsten Harrild, Cynthia Fraser, Tara Gurung, Douglas G Altman, Andrew H Briggs, Peter Fayers, Craig R Ramsay, John D Norrie, Ian M Harvey, Brian Buckley, Jonathan A Cook, DELTA group

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Abstract

Randomised controlled trials (RCTs) are widely accepted as the preferred study design for evaluating healthcare interventions. When the sample size is determined, a (target) difference is typically specified that the RCT is designed to detect. This provides reassurance that the study will be informative, i.e., should such a difference exist, it is likely to be detected with the required statistical precision. The aim of this review was to identify potential methods for specifying the target difference in an RCT sample size calculation.

Original language	English
Article number	e1001645
Number of pages	16
Journal	PLoS Medicine
Volume	11
Issue number	5
DOIs	https://doi.org/10.1371/journal.pmed.1001645
Publication status	Published - 13 May 2014

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10.1371/journal.pmed.1001645

Hislop 2014
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Hislop, J., Adewuyi, T. E., Vale, L. D., Harrild, K., Fraser, C., Gurung, T., Altman, D. G., Briggs, A. H., Fayers, P., Ramsay, C. R., Norrie, J. D., Harvey, I. M., Buckley, B., Cook, J. A., & DELTA group (2014). Methods for specifying the target difference in a randomised controlled trial: the Difference ELicitation in TriAls (DELTA) systematic review. PLoS Medicine, 11(5), Article e1001645. https://doi.org/10.1371/journal.pmed.1001645

Hislop, J, Adewuyi, TE, Vale, LD, Harrild, K, Fraser, C, Gurung, T, Altman, DG, Briggs, AH, Fayers, P , Ramsay, CR, Norrie, JD, Harvey, IM, Buckley, B, Cook, JA & DELTA group 2014, 'Methods for specifying the target difference in a randomised controlled trial: the Difference ELicitation in TriAls (DELTA) systematic review', PLoS Medicine, vol. 11, no. 5, e1001645. https://doi.org/10.1371/journal.pmed.1001645

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Methods for specifying the target difference in a randomised controlled trial: the Difference ELicitation in TriAls (DELTA) systematic review

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