Methyl-4-hydroxy-2-(2-hydroxypropan-2-yl)-6-methyl-2,3-dihydrobenzofuran-5-carboxylate

Rishi Vachaspathy Astakala; Gagan Preet; Rainer Ebel; Marcel Jaspars

doi:10.3390/M1697

Methyl-4-hydroxy-2-(2-hydroxypropan-2-yl)-6-methyl-2,3-dihydrobenzofuran-5-carboxylate

Rishi Vachaspathy Astakala, Gagan Preet, Rainer Ebel, Marcel Jaspars

Research output: Contribution to journal › Article › peer-review

3 Downloads (Pure)

Abstract

Microorganisms are an important source of compounds that are pharmaceutically active, both as leads and as scaffolds for synthesis. Often, interesting chemistry is uncovered by exploring new biomes, of which the Chilean Atacama Desert is a prime example. This paper describes the isolation and structural characterisation, using HR-LCMS and 1D and 2D NMR, of a new compound belonging to a family of compounds called radstrictins. The compound was isolated from a fungus, that had itself been isolated from a soil sample from the Atacama Desert. The compound was tested against pathogenic strains associated with bovine mastitis, but was found to be devoid of antimicrobial activity.

Original language	English
Article number	M1697
Journal	MolBank
Volume	2023
Issue number	3
DOIs	https://doi.org/10.3390/M1697
Publication status	Published - 19 Jul 2023

Bibliographical note

Acknowledgments
The authors would like to thank Albrn Care India for their continued support. The authors would also like to thank Harpreet Oberoi and Aparna Koride for their continued support. The authors would additionally like to thank Russell Gray for his support and help in conducting the NMR experiments. The collection was carried out in collaboration with Michael Goodfellow, University of Newcastle, and Juan Asenjo and Barbara Andrews, University of Chile.

Funding
The collection of materials was carried out with the financial support of the Royal Society International Joint Project Award JP100654 to Prof Alan Bull, University of Kent.

Data Availability Statement

The spectroscopic data presented in this study are available as supplementary materials.

Keywords

radstrictins
natural products
Atacama desert
fungi
bovine mastitis
2D NMR
high-resolution MS

Access to Document

10.3390/M1697

Astakala_etal_M_Methyl-4-hydroxy_VOR
© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Final published version, 1.26 MBLicence: CC BY

Cite this

@article{6d0d9dd2859949969d4b55c050d1f299,

title = "Methyl-4-hydroxy-2-(2-hydroxypropan-2-yl)-6-methyl-2,3-dihydrobenzofuran-5-carboxylate",

abstract = "Microorganisms are an important source of compounds that are pharmaceutically active, both as leads and as scaffolds for synthesis. Often, interesting chemistry is uncovered by exploring new biomes, of which the Chilean Atacama Desert is a prime example. This paper describes the isolation and structural characterisation, using HR-LCMS and 1D and 2D NMR, of a new compound belonging to a family of compounds called radstrictins. The compound was isolated from a fungus, that had itself been isolated from a soil sample from the Atacama Desert. The compound was tested against pathogenic strains associated with bovine mastitis, but was found to be devoid of antimicrobial activity.",

keywords = "radstrictins, natural products, Atacama desert, fungi, bovine mastitis, 2D NMR, high-resolution MS",

author = "Astakala, {Rishi Vachaspathy} and Gagan Preet and Rainer Ebel and Marcel Jaspars",

note = "Acknowledgments The authors would like to thank Albrn Care India for their continued support. The authors would also like to thank Harpreet Oberoi and Aparna Koride for their continued support. The authors would additionally like to thank Russell Gray for his support and help in conducting the NMR experiments. The collection was carried out in collaboration with Michael Goodfellow, University of Newcastle, and Juan Asenjo and Barbara Andrews, University of Chile. Funding The collection of materials was carried out with the financial support of the Royal Society International Joint Project Award JP100654 to Prof Alan Bull, University of Kent.",

year = "2023",

month = jul,

day = "19",

doi = "10.3390/M1697",

language = "English",

volume = "2023",

journal = "MolBank",

issn = "1422-8599",

publisher = "MDPI AG",

number = "3",

}

TY - JOUR

T1 - Methyl-4-hydroxy-2-(2-hydroxypropan-2-yl)-6-methyl-2,3-dihydrobenzofuran-5-carboxylate

AU - Astakala, Rishi Vachaspathy

AU - Preet, Gagan

AU - Ebel, Rainer

AU - Jaspars, Marcel

N1 - Acknowledgments The authors would like to thank Albrn Care India for their continued support. The authors would also like to thank Harpreet Oberoi and Aparna Koride for their continued support. The authors would additionally like to thank Russell Gray for his support and help in conducting the NMR experiments. The collection was carried out in collaboration with Michael Goodfellow, University of Newcastle, and Juan Asenjo and Barbara Andrews, University of Chile. Funding The collection of materials was carried out with the financial support of the Royal Society International Joint Project Award JP100654 to Prof Alan Bull, University of Kent.

PY - 2023/7/19

Y1 - 2023/7/19

N2 - Microorganisms are an important source of compounds that are pharmaceutically active, both as leads and as scaffolds for synthesis. Often, interesting chemistry is uncovered by exploring new biomes, of which the Chilean Atacama Desert is a prime example. This paper describes the isolation and structural characterisation, using HR-LCMS and 1D and 2D NMR, of a new compound belonging to a family of compounds called radstrictins. The compound was isolated from a fungus, that had itself been isolated from a soil sample from the Atacama Desert. The compound was tested against pathogenic strains associated with bovine mastitis, but was found to be devoid of antimicrobial activity.

AB - Microorganisms are an important source of compounds that are pharmaceutically active, both as leads and as scaffolds for synthesis. Often, interesting chemistry is uncovered by exploring new biomes, of which the Chilean Atacama Desert is a prime example. This paper describes the isolation and structural characterisation, using HR-LCMS and 1D and 2D NMR, of a new compound belonging to a family of compounds called radstrictins. The compound was isolated from a fungus, that had itself been isolated from a soil sample from the Atacama Desert. The compound was tested against pathogenic strains associated with bovine mastitis, but was found to be devoid of antimicrobial activity.

KW - radstrictins

KW - natural products

KW - Atacama desert

KW - fungi

KW - bovine mastitis

KW - 2D NMR

KW - high-resolution MS

U2 - 10.3390/M1697

DO - 10.3390/M1697

M3 - Article

SN - 1422-8599

VL - 2023

JO - MolBank

JF - MolBank

IS - 3

M1 - M1697

ER -

Methyl-4-hydroxy-2-(2-hydroxypropan-2-yl)-6-methyl-2,3-dihydrobenzofuran-5-carboxylate

Abstract

Bibliographical note

Data Availability Statement

Keywords

Access to Document

Fingerprint

Cite this