Model thrombi formed under flow reveal the role of factor XIII-mediated cross-linking in resistance to fibrinolysis

Nicola Jane Mutch; J S Koikkalainen; S R Fraser; K M Duthie; M Griffin; Jennifer Mitchell; H G Watson; N A Booth

doi:10.1111/j.1538-7836.2010.03963.x

Model thrombi formed under flow reveal the role of factor XIII-mediated cross-linking in resistance to fibrinolysis

Nicola Jane Mutch, J S Koikkalainen, S R Fraser, K M Duthie, M Griffin, Jennifer Mitchell, H G Watson, N A Booth

Applied Medicine

Research output: Contribution to journal › Article › peer-review

64 Citations (Scopus)

Abstract

Activated factor XIII (FXIIIa), a transglutaminase, introduces fibrin-fibrin and fibrin-inhibitor cross-links, resulting in more mechanically stable clots. The impact of cross-linking on resistance to fibrinolysis has proved challenging to evaluate quantitatively.

Original language	English
Pages (from-to)	2017-2024
Number of pages	8
Journal	Journal of Thrombosis and Haemostasis
Volume	8
Issue number	9
Early online date	24 Jun 2010
DOIs	https://doi.org/10.1111/j.1538-7836.2010.03963.x
Publication status	Published - 1 Sept 2010

Keywords

factor XIII
fibrinolysis
flow
stability
thrombi

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title = "Model thrombi formed under flow reveal the role of factor XIII-mediated cross-linking in resistance to fibrinolysis",

abstract = "Activated factor XIII (FXIIIa), a transglutaminase, introduces fibrin-fibrin and fibrin-inhibitor cross-links, resulting in more mechanically stable clots. The impact of cross-linking on resistance to fibrinolysis has proved challenging to evaluate quantitatively.",

keywords = "factor XIII, fibrinolysis, flow, stability, thrombi",

author = "Mutch, {Nicola Jane} and Koikkalainen, {J S} and Fraser, {S R} and Duthie, {K M} and M Griffin and Jennifer Mitchell and Watson, {H G} and Booth, {N A}",

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T1 - Model thrombi formed under flow reveal the role of factor XIII-mediated cross-linking in resistance to fibrinolysis

AU - Mutch, Nicola Jane

AU - Koikkalainen, J S

AU - Fraser, S R

AU - Duthie, K M

AU - Griffin, M

AU - Mitchell, Jennifer

AU - Watson, H G

AU - Booth, N A

PY - 2010/9/1

Y1 - 2010/9/1

N2 - Activated factor XIII (FXIIIa), a transglutaminase, introduces fibrin-fibrin and fibrin-inhibitor cross-links, resulting in more mechanically stable clots. The impact of cross-linking on resistance to fibrinolysis has proved challenging to evaluate quantitatively.

AB - Activated factor XIII (FXIIIa), a transglutaminase, introduces fibrin-fibrin and fibrin-inhibitor cross-links, resulting in more mechanically stable clots. The impact of cross-linking on resistance to fibrinolysis has proved challenging to evaluate quantitatively.

KW - factor XIII

KW - fibrinolysis

KW - flow

KW - stability

KW - thrombi

U2 - 10.1111/j.1538-7836.2010.03963.x

DO - 10.1111/j.1538-7836.2010.03963.x

M3 - Article

C2 - 20586921

VL - 8

SP - 2017

EP - 2024

JO - Journal of Thrombosis and Haemostasis

JF - Journal of Thrombosis and Haemostasis

IS - 9

ER -

Model thrombi formed under flow reveal the role of factor XIII-mediated cross-linking in resistance to fibrinolysis

Abstract

Keywords

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