Modelling the mechanoreceptor’s dynamic behaviour

Zhuoyi Song, Robert W. Banks, Guy S. Bewick

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13 Citations (Scopus)
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All sensory receptors adapt, i.e. they constantly adjust their sensitivity to external stimuli to match the current demands of the natural environment. Electrophysiological responses of sensory receptors from widely different modalities seem to exhibit common features related to adaptation, and these features can be used to examine the underlying sensory transduction mechanisms. Among the principal senses, mechanosensation remains the least understood at the cellular level. To gain greater insights into mechanosensory signalling, we investigated if mechanosensation displayed adaptive dynamics that could be explained by similar biophysical mechanisms in other sensory modalities. To do this, we adapted a fly photoreceptor model to describe the primary transduction process for a stretch-sensitive mechanoreceptor, taking into account the viscoelastic properties of the accessory muscle fibres and the biophysical properties of known mechanosensitive channels (MSCs). The model's output is in remarkable agreement with the electrical properties of a primary ending in an isolated decapsulated spindle; ramp-and-hold stretch evokes a characteristic pattern of potential change, consisting of a large dynamic depolarization during the ramp phase and a smaller static depolarization during the hold phase. The initial dynamic component is likely to be caused by a combination of the mechanical properties of the muscle fibres and a refractory state in the MSCs. Consistent with the literature, the current model predicts that the dynamic component is due to a rapid stress increase during the ramp. More novel predictions from the model are the mechanisms to explain the initial peak in the dynamic component. At the onset of the ramp, all MSCs are sensitive to external stimuli, but as they become refractory (inactivated), fewer MSCs are able to respond to the continuous stretch, causing a sharp decrease after the peak response. The same mechanism could contribute a faster component in the ‘sensory habituation’ of mechanoreceptors, in which a receptor responds more strongly to the first stimulus episode during repetitive stimulation.
Original languageEnglish
Pages (from-to)243-254
Number of pages12
JournalJournal of Anatomy
Issue number2
Early online date25 Jun 2015
Publication statusPublished - Aug 2015

Bibliographical note

This study was funded by an EPSRC-funded 2020 Science Fellowship (EP/I017909/1). Z.S would like to thank the organisers for the invitation to present at the symposium ‘A Mechano-reception to Celebrate Bob Banks’ Career in Stretching the Imagination’. This paper summarizes the contents of the talk given at the symposium.


  • biophysical model
  • fly photoreceptor
  • refractory period
  • sensory adaptation
  • sensory habituation
  • stochastic adaptive sampling
  • stretch-sensitive mechanoreceptor


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