Modulation of meiotic homologous recombination by DNA helicases

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DNA helicases are ATP-driven motor proteins which translocate along DNA capable of dismantling DNA-DNA interactions and/or removing proteins bound to DNA. These biochemical capabilities make DNA helicases main regulators of crucial DNA metabolic processes, including DNA replication, DNA repair, and genetic recombination. This budding topic will focus on reviewing the function of DNA helicases important for homologous recombination during meiosis, and discuss recent advances in how these modulators of meiotic recombination are themselves regulated. The emphasis is placed on work in the two model yeasts, Saccharomyces cerevisiae and Schizosaccharomyces pombe, which has vastly expanded our understanding of meiotic homologous recombination, a process whose correct execution is instrumental for healthy gamete formation, and thus functioning sexual reproduction
Original languageEnglish
Pages (from-to)195-203
Number of pages9
Issue number5
Early online date27 Jan 2017
Publication statusPublished - 4 May 2017

Bibliographical note

Acknowledgements I am grateful to Simon D. Brown, Anne D. Donaldson and Takashi Kubota for critically reading the manuscript


  • DNA helicases
  • homologous recombination
  • meiosis
  • crossover
  • template choice


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